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Pmvk Gene Detail
Summary
  • Symbol
    Pmvk
  • Name
    phosphomevalonate kinase
  • Synonyms
    1110011E12Rik, 2900002L22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915853
    NCBI Gene: 68603
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89361848-89376320 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    479 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915853
 protein coding gene Chr3:89361848-89376321 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027442
 protein coding gene Chr3:89676447-89685751 (+)
A/J MGP_AJ_G0027406
 protein coding gene Chr3:86708910-86719217 (+)
AKR/J MGP_AKRJ_G0027370
 protein coding gene Chr3:88809766-88820467 (+)
BALB/cJ MGP_BALBcJ_G0027415
 protein coding gene Chr3:86676587-86686849 (+)
C3H/HeJ MGP_C3HHeJ_G0027157
 protein coding gene Chr3:89011509-89023501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027861
 protein coding gene Chr3:93066920-93076209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025213
 protein coding gene Chr3:82186719-82200925 (+)
CAST/EiJ MGP_CASTEiJ_G0026603
 protein coding gene Chr3:89369038-89379868 (+)
CBA/J MGP_CBAJ_G0027131
 protein coding gene Chr3:96256972-96272580 (+)
DBA/2J MGP_DBA2J_G0027269
 protein coding gene Chr3:86086332-86096117 (+)
FVB/NJ MGP_FVBNJ_G0027237
 protein coding gene Chr3:84428226-84437598 (+)
LP/J MGP_LPJ_G0027378
 protein coding gene Chr3:90754733-90765447 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027257
 protein coding gene Chr3:102462015-102472660 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027920
 protein coding gene Chr3:88562733-88573358 (+)
PWK/PhJ MGP_PWKPhJ_G0026337
 protein coding gene Chr3:85964705-85974010 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026156
 protein coding gene Chr3:87741690-87752311 (+)
WSB/EiJ MGP_WSBEiJ_G0026685
 protein coding gene Chr3:88958393-88969120 (+)



Homology
more
  • Human Ortholog
    PMVK, phosphomevalonate kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PMVK, phosphomevalonate kinase
  • Synonyms
    HUMPMKI, PMK, PMKA, PMKASE, POROK1
  • Links
    NCBI Gene ID: 10654
    neXtProt AC: NX_Q15126
    UniProt: Q15126

  • Chr Location
    1q21.3; chr1:154924740-154942658 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PMVK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    6
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Pmvk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027952 Ensembl Gene Model | MGI Sequence Detail 14473 C57BL/6J ±  kb
transcript ENSMUST00000029564 Ensembl | MGI Sequence Detail 1194 Not Applicable  
polypeptide ENSMUSP00000029564 Ensembl | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917467, MGI:2139922
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory