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Mthfd2l Gene Detail
Summary
  • Symbol
    Mthfd2l
  • Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
  • Synonyms
    1110019K23Rik, C630010D07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915871
    NCBI Gene: 665563
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91078976-91169227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2663 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915871
 protein coding gene Chr5:91078704-91169227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029733
 protein coding gene Chr5:92011056-92101280 (+)
A/J MGP_AJ_G0029699
 protein coding gene Chr5:88392145-88481401 (+)
AKR/J MGP_AKRJ_G0029645
 protein coding gene Chr5:91242345-91344683 (+)
BALB/cJ MGP_BALBcJ_G0029709
 protein coding gene Chr5:89281052-89367605 (+)
C3H/HeJ MGP_C3HHeJ_G0029432
 protein coding gene Chr5:91666842-91758121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030163
 protein coding gene Chr5:95692744-95781953 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027399
 protein coding gene Chr5:84075095-84167119 (+)
CAST/EiJ MGP_CASTEiJ_G0028842
 protein coding gene Chr5:91038981-91131406 (+)
CBA/J MGP_CBAJ_G0029402
 protein coding gene Chr5:98968895-99064233 (+)
DBA/2J MGP_DBA2J_G0029546
 protein coding gene Chr5:88456026-88545866 (+)
FVB/NJ MGP_FVBNJ_G0029505
 protein coding gene Chr5:87303566-87393254 (+)
LP/J MGP_LPJ_G0029634
 protein coding gene Chr5:92396850-92489280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029534
 protein coding gene Chr5:103938391-104036015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030197
 protein coding gene Chr5:90807903-90898537 (+)
PWK/PhJ MGP_PWKPhJ_G0028561
 protein coding gene Chr5:87517500-87606722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028396
 protein coding gene Chr5:90192747-90283097 (+)
WSB/EiJ MGP_WSBEiJ_G0028921
 protein coding gene Chr5:91238571-91341971 (+)



Homology
more
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
  • Links
    NCBI Gene ID: 441024
    neXtProt AC: NX_Q9H903
    UniProt: Q9H903

  • Chr Location
    4q13.3; chr4:74114174-74303099 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    159
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029376 Ensembl Gene Model | MGI Sequence Detail 90252 C57BL/6J ±  kb
    transcript ENSMUST00000071652 Ensembl | MGI Sequence Detail 2159 Not Applicable  
    polypeptide ENSMUSP00000071578 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030938 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
      (term hierarchy)
    • EC
      1.5.1.15, 1.5.1.5, 3.5.4.9
    • InterPro Domains
      IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
      IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
      IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 29
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:3529335
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory