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Smyd2 Gene Detail
Summary
  • Symbol
    Smyd2
  • Name
    SET and MYND domain containing 2
  • Synonyms
    1110020E07Rik, KMT3C, Zmynd14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915889
    NCBI Gene: 226830
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:189612689-189654560 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 95.03 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915889
 protein coding gene Chr1:189612689-189654758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016930
 protein coding gene Chr1:196816858-196861127 (-)
A/J MGP_AJ_G0016909
 protein coding gene Chr1:188758756-188808355 (-)
AKR/J MGP_AKRJ_G0016874
 protein coding gene Chr1:194325621-194374580 (-)
BALB/cJ MGP_BALBcJ_G0016867
 protein coding gene Chr1:189434007-189477884 (-)
C3H/HeJ MGP_C3HHeJ_G0016691
 protein coding gene Chr1:195193315-195237732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017330
 protein coding gene Chr1:203098693-203143989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015037
 protein coding gene Chr1:179684850-179726117 (-)
CAST/EiJ MGP_CASTEiJ_G0016274
 protein coding gene Chr1:194757620-194806355 (-)
CBA/J MGP_CBAJ_G0016665
 protein coding gene Chr1:210666706-210723194 (-)
DBA/2J MGP_DBA2J_G0016771
 protein coding gene Chr1:187499434-187542209 (-)
FVB/NJ MGP_FVBNJ_G0016767
 protein coding gene Chr1:185613309-185655940 (-)
LP/J MGP_LPJ_G0016846
 protein coding gene Chr1:197990401-198036050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016799
 protein coding gene Chr1:217375224-217423460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017367
 protein coding gene Chr1:194243769-194285086 (-)
PWK/PhJ MGP_PWKPhJ_G0016061
 protein coding gene Chr1:186760414-186803250 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015837
 protein coding gene Chr1:193207041-193249579 (-)
WSB/EiJ MGP_WSBEiJ_G0016336
 protein coding gene Chr1:194438137-194481441 (-)



Homology
more
  • Human Ortholog
    SMYD2, SET and MYND domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMYD2, SET and MYND domain containing 2
  • Synonyms
    HSKM-B, KMT3C, ZMYND14
  • Links
    NCBI Gene ID: 56950
    neXtProt AC: NX_Q9NRG4
    UniProt: Q9NRG4

  • Chr Location
    1q32.3; chr1:214281102-214337131 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased circulating total and LDL cholesterol levels and decreased circulating sodium and chloride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    34
  • cDNA Data
    80
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026603 Ensembl Gene Model | MGI Sequence Detail 41872 C57BL/6J ±  kb
    transcript ENSMUST00000027897 Ensembl | MGI Sequence Detail 1680 Not Applicable  
    polypeptide ENSMUSP00000027897 Ensembl | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 80
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory