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Slc44a2 Gene Detail
Summary
  • Symbol
    Slc44a2
  • Name
    solute carrier family 44, member 2
  • Synonyms
    1110028E10Rik, CTL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915932
    NCBI Gene: 68682
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21232015-21266324 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    968 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915932
 protein coding gene Chr9:21231994-21266324 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034450
 protein coding gene Chr9:18526363-18563985 (+)
A/J MGP_AJ_G0034428
 protein coding gene Chr9:18208437-18243886 (+)
AKR/J MGP_AKRJ_G0034355
 protein coding gene Chr9:18544645-18582609 (+)
BALB/cJ MGP_BALBcJ_G0034419
 protein coding gene Chr9:18098547-18133436 (+)
C3H/HeJ MGP_C3HHeJ_G0034131
 protein coding gene Chr9:18848266-18889058 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034940
 protein coding gene Chr9:19271908-19312298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031870
 protein coding gene Chr9:17333765-17367595 (+)
CAST/EiJ MGP_CASTEiJ_G0033454
 protein coding gene Chr9:18673751-18713832 (+)
CBA/J MGP_CBAJ_G0034104
 protein coding gene Chr9:19992281-20036579 (+)
DBA/2J MGP_DBA2J_G0034263
 protein coding gene Chr9:18180563-18214947 (+)
FVB/NJ MGP_FVBNJ_G0034206
 protein coding gene Chr9:17711015-17746577 (+)
LP/J MGP_LPJ_G0034348
 protein coding gene Chr9:18693861-18727894 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034249
 protein coding gene Chr9:21595270-21632877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034960
 protein coding gene Chr9:18504866-18542613 (+)
PWK/PhJ MGP_PWKPhJ_G0033160
 protein coding gene Chr9:18165248-18206338 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032994
 protein coding gene Chr9:18550306-18586062 (+)
WSB/EiJ MGP_WSBEiJ_G0033569
 protein coding gene Chr9:18222216-18257549 (+)



Homology
more
  • Human Ortholog
    SLC44A2, solute carrier family 44 member 2 (CTL2 blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC44A2, solute carrier family 44 member 2 (CTL2 blood group)
  • Synonyms
    CTL2, PP1292
  • Links
    NCBI Gene ID: 57153
    neXtProt AC: NX_Q8IWA5
    UniProt: Q8IWA5

  • Chr Location
    19p13.2; chr19:10602455-10644557 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cochlear hair cell loss, spiral ganglion degeneration, and progressive sensorineural hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    16
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68682 NCBI Gene Model | MGI Sequence Detail 34310 C57BL/6J ±  kb
    transcript NM_001359227 RefSeq | MGI Sequence Detail 3629 C57BL/6  
    polypeptide Q8BY89 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015144 choline transporter-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR007603 Choline transporter-like
    • GlyGen
      Q8BY89 4 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory