Abhd4 MGI Mouse Gene Detail - MGI:1915938 - abhydrolase domain containing 4

Symbol

Abhd4
Name

abhydrolase domain containing 4
Synonyms

1110035H23Rik

Feature Type

protein coding gene
IDs

MGI:1915938
NCBI Gene: 105501
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:54491586-54506626 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.71 cM
Mapping Data

2 experiments

SNPs within 2kb

424 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915938	protein coding gene	Chr14:54491586-54508094 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021304	protein coding gene	Chr14:48188834-48207177 (+)
A/J	MGP_AJ_G0021263	protein coding gene	Chr14:47275210-47291389 (+)
AKR/J	MGP_AKRJ_G0021239	protein coding gene	Chr14:48986246-49002457 (+)
BALB/cJ	MGP_BALBcJ_G0021267	protein coding gene	Chr14:47246623-47262772 (+)
C3H/HeJ	MGP_C3HHeJ_G0021047	protein coding gene	Chr14:48665565-48683019 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021706	protein coding gene	Chr14:50657583-50668927 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019250	protein coding gene	Chr14:45688703-45705007 (+)
CAST/EiJ	MGP_CASTEiJ_G0020566	protein coding gene	Chr14:44901124-44917508 (+)
CBA/J	MGP_CBAJ_G0021014	protein coding gene	Chr14:52145147-52162142 (+)
DBA/2J	MGP_DBA2J_G0021135	protein coding gene	Chr14:47021171-47038095 (+)
FVB/NJ	MGP_FVBNJ_G0021117	protein coding gene	Chr14:46473468-46489509 (+)
LP/J	MGP_LPJ_G0021209	protein coding gene	Chr14:49215814-49233370 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021141	protein coding gene	Chr14:51584807-51602812 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021732	protein coding gene	Chr14:48165584-48183977 (+)
PWK/PhJ	MGP_PWKPhJ_G0020312	protein coding gene	Chr14:43543764-43560307 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020140	protein coding gene	Chr14:44149455-44182821 (+)
WSB/EiJ	MGP_WSBEiJ_G0020619	protein coding gene	Chr14:48459746-48475914 (+)

Human Ortholog

ABHD4, abhydrolase domain containing 4, N-acyl phospholipase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABHD4, abhydrolase domain containing 4, N-acyl phospholipase B
Synonyms

ABH4
Links

HGNC:20154

NCBI Gene ID: 63874

neXtProt AC: NX_Q8TB40

UniProt: Q8TB40
Chr Location

14q11.2; chr14:22598290-22612963 (+) GRCh38

MGI Vertebrate Homology

Abhd4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABHD4
Gene Tree

Abhd4

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Abhd4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele are viable, healthy and behaviorally normal but show deregulated N-acyl phospholipid metabolism in brain.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

60
cDNA Data

127
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abhd4

ZFIN abhd4

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All Sequences

77
RefSeq

6
UniProt

9
CCDS

CCDS56954.1, CCDS56955.1

Ensembl

ENSMUSG00000040997 (Evidence)
NCBI Gene

105501

			Length	Strain/Species	Flank
genomic	105501	NCBI Gene Model \| MGI Sequence Detail	15041	C57BL/6J	± kb
transcript	NM_001205181	RefSeq \| MGI Sequence Detail	2661	C57BL/6
polypeptide	Q8VD66	UniProt \| EBI \| MGI Sequence Detail	342	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000003577 (lyso)-N-acylphosphatidylethanolamine lipase

(term hierarchy)
EC

3.1.1.-
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR000073 Alpha/beta hydrolase fold-1

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All nucleic 127

cDNA 127

Microarray probesets 4

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MGI:2145640

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abhd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125618	Chr14:54491104-54491114 (+)	-477 bp
Tssr4409	Chr14:54491123-54491128 (+)	-460 bp
Tssr125619	Chr14:54491581-54491704 (+)	57 bp
Tssr125620	Chr14:54496684-54496698 (+)	5,105 bp
Tssr125621	Chr14:54496699-54496757 (+)	5,142 bp
Tssr125622	Chr14:54506177-54506181 (+)	14,593 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24