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Gtf2f2 Gene Detail
Summary
  • Symbol
    Gtf2f2
  • Name
    general transcription factor IIF, polypeptide 2
  • Synonyms
    1110031C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915955
    NCBI Gene: 68705
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:76134377-76248305 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 40.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2393 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915955
 protein coding gene Chr14:76134368-76248356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021576
 protein coding gene Chr14:70773037-70896789 (-)
A/J MGP_AJ_G0021534
 protein coding gene Chr14:69159367-69275099 (-)
AKR/J MGP_AKRJ_G0021511
 protein coding gene Chr14:71228528-71347732 (-)
BALB/cJ MGP_BALBcJ_G0021541
 protein coding gene Chr14:68957115-69069411 (-)
C3H/HeJ MGP_C3HHeJ_G0021318
 protein coding gene Chr14:70942612-71056437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021981
 protein coding gene Chr14:73886649-74006038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019519
 protein coding gene Chr14:66775089-66886408 (-)
CAST/EiJ MGP_CASTEiJ_G0020835
 protein coding gene Chr14:67626987-67752321 (-)
CBA/J MGP_CBAJ_G0021286
 protein coding gene Chr14:76246380-76377387 (-)
DBA/2J MGP_DBA2J_G0021409
 protein coding gene Chr14:68565953-68681220 (-)
FVB/NJ MGP_FVBNJ_G0021387
 protein coding gene Chr14:67909118-68022298 (-)
LP/J MGP_LPJ_G0021479
 protein coding gene Chr14:71933374-72052202 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021414
 protein coding gene Chr14:74969392-75088634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022004
 protein coding gene Chr14:70506167-70621659 (-)
PWK/PhJ MGP_PWKPhJ_G0020578
 protein coding gene Chr14:65307373-65424949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020415
 protein coding gene Chr14:66473170-66596699 (-)
WSB/EiJ MGP_WSBEiJ_G0020888
 protein coding gene Chr14:70841592-70963620 (-)



Homology
more
  • Human Ortholog
    GTF2F2, general transcription factor IIF subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2F2, general transcription factor IIF subunit 2
  • Synonyms
    BTF4, RAP30, TF2F2, TFIIF
  • Links
    NCBI Gene ID: 2963
    neXtProt AC: NX_P13984
    UniProt: P13984

  • Chr Location
    13q14.12-q14.13; chr13:45120510-45284893 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    27
  • cDNA Data
    56
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067995 Ensembl Gene Model | MGI Sequence Detail 113929 C57BL/6J ±  kb
transcript ENSMUST00000088922 Ensembl | MGI Sequence Detail 1467 Not Applicable  
polypeptide ENSMUSP00000086312 Ensembl | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008316 general transcription factor IIF subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR040450 TFIIF beta subunit, HTH domain
    IPR040504 TFIIF, beta subunit, N-terminal
    IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
    IPR003196 Transcription initiation factor IIF, beta subunit
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
  • GlyGen
    Q8R0A0 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 56
    cDNA 56

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145624
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory