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Abhd11 Gene Detail
Summary
  • Symbol
    Abhd11
  • Name
    abhydrolase domain containing 11
  • Synonyms
    1110054D16Rik, A630008N09Rik, Wbscr21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916008
    NCBI Gene: 68758
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135038006-135041029 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916008
 protein coding gene Chr5:135038006-135041029 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030169
 protein coding gene Chr5:139486449-139489206 (+)
A/J MGP_AJ_G0030137
 protein coding gene Chr5:133532679-133535436 (+)
AKR/J MGP_AKRJ_G0030070
 protein coding gene Chr5:137873432-137876196 (+)
BALB/cJ MGP_BALBcJ_G0030147
 protein coding gene Chr5:134888407-134891171 (+)
C3H/HeJ MGP_C3HHeJ_G0029863
 protein coding gene Chr5:138434607-138437370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030600
 protein coding gene Chr5:144723215-144725978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027823
 protein coding gene Chr5:127832513-127835245 (+)
CAST/EiJ MGP_CASTEiJ_G0029272
 protein coding gene Chr5:137861321-137864331 (+)
CBA/J MGP_CBAJ_G0029833
 protein coding gene Chr5:150372376-150375139 (+)
DBA/2J MGP_DBA2J_G0029984
 protein coding gene Chr5:133429782-133433204 (+)
FVB/NJ MGP_FVBNJ_G0029939
 protein coding gene Chr5:132568017-132570774 (+)
LP/J MGP_LPJ_G0030072
 protein coding gene Chr5:139947167-139949930 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029971
 protein coding gene Chr5:153392295-153395052 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030640
 protein coding gene Chr5:137619162-137621919 (+)
PWK/PhJ MGP_PWKPhJ_G0028987
 protein coding gene Chr5:132478017-132481084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028822
 protein coding gene Chr5:135181975-135184949 (+)
WSB/EiJ MGP_WSBEiJ_G0029346
 protein coding gene Chr5:138370239-138373271 (+)



Homology
more
  • Human Ortholog
    ABHD11, abhydrolase domain containing 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABHD11, abhydrolase domain containing 11
  • Synonyms
    PP1226, WBSCR21
  • Links
    NCBI Gene ID: 83451
    neXtProt AC: NX_Q8NFV4
    UniProt: Q8NFV4

  • Chr Location
    7q11.23; chr7:73736094-73738852 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display resistance to high-fat diet induced obesity and multiple eye abnormalities resulting in blindness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    11
  • cDNA Data
    73
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68758 NCBI Gene Model | MGI Sequence Detail 3024 C57BL/6J ±  kb
    transcript NM_145215 RefSeq | MGI Sequence Detail 1493 C57BL/6  
    polypeptide Q8K4F5 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 73
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442950
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory