About   Help   FAQ
Smpdl3b Gene Detail
Summary
  • Symbol
    Smpdl3b
  • Name
    sphingomyelin phosphodiesterase, acid-like 3B
  • Synonyms
    1110054A24Rik, Asml3b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916022
    NCBI Gene: 100340
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132460277-132484558 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    878 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916022
 protein coding gene Chr4:132460277-132484563 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028878
 protein coding gene Chr4:134916600-134942844 (-)
A/J MGP_AJ_G0028837
 protein coding gene Chr4:129298223-129322556 (-)
AKR/J MGP_AKRJ_G0028790
 protein coding gene Chr4:132943174-132967441 (-)
BALB/cJ MGP_BALBcJ_G0028860
 protein coding gene Chr4:129916745-129941916 (-)
C3H/HeJ MGP_C3HHeJ_G0028574
 protein coding gene Chr4:133204542-133228119 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029302
 protein coding gene Chr4:139787754-139813587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026573
 protein coding gene Chr4:122373787-122400175 (-)
CAST/EiJ MGP_CASTEiJ_G0028007
 protein coding gene Chr4:131270336-131298060 (-)
CBA/J MGP_CBAJ_G0028540
 protein coding gene Chr4:143366499-143390939 (-)
DBA/2J MGP_DBA2J_G0028689
 protein coding gene Chr4:129717016-129741325 (-)
FVB/NJ MGP_FVBNJ_G0028656
 protein coding gene Chr4:128577629-128602947 (-)
LP/J MGP_LPJ_G0028790
 protein coding gene Chr4:135065588-135090386 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028682
 protein coding gene Chr4:147959198-147985946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029340
 protein coding gene Chr4:133361416-133386877 (-)
PWK/PhJ MGP_PWKPhJ_G0027728
 protein coding gene Chr4:126414353-126439667 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027554
 protein coding gene Chr4:129201866-129229406 (-)
WSB/EiJ MGP_WSBEiJ_G0028087
 protein coding gene Chr4:133528619-133553632 (-)



Homology
more
  • Human Ortholog
    SMPDL3B, sphingomyelin phosphodiesterase acid like 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMPDL3B, sphingomyelin phosphodiesterase acid like 3B
  • Synonyms
    ASML3B
  • Links
    NCBI Gene ID: 27293
    neXtProt AC: NX_Q92485
    UniProt: Q92485

  • Chr Location
    1p35.3; chr1:27935000-27959157 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal but exhibit an enhanced inflammatory response in models of Toll-like receptor (TLR)-dependent peritonitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100340 NCBI Gene Model | MGI Sequence Detail 24282 C57BL/6J ±  kb
    transcript NM_133888 RefSeq | MGI Sequence Detail 1925 C57BL/6  
    polypeptide P58242 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015297 acid sphingomyelinase-like phosphodiesterase 3b
      (term hierarchy)
    • PDB
      5KAR, 5KAS
    • EC
      3.1.4.-
    • InterPro Domains
      IPR041805 Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain
      IPR017064 Acid sphingomyelinase-like phosphodiesterase, predicted
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR045473 Sphingomyelin phosphodiesterase, C-terminal domain
    • GlyGen
      P58242 6 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140498
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory