Srpx2 MGI Mouse Gene Detail - MGI:1916042 - sushi-repeat-containing protein, X-linked 2

Symbol

Srpx2
Name

sushi-repeat-containing protein, X-linked 2
Synonyms

1110039C07Rik

Feature Type

protein coding gene
IDs

MGI:1916042
NCBI Gene: 68792
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:132809175-132833195 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 55.47 cM
Mapping Data

1 experiment

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916042	protein coding gene	ChrX:132809155-132833195 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036058	protein coding gene	ChrX:131051567-131074329 (+)
A/J	MGP_AJ_G0036040	protein coding gene	ChrX:130481118-130503245 (+)
AKR/J	MGP_AKRJ_G0035959	protein coding gene	ChrX:134649526-134672428 (+)
BALB/cJ	MGP_BALBcJ_G0036031	protein coding gene	ChrX:128929381-128952620 (+)
C3H/HeJ	MGP_C3HHeJ_G0035735	protein coding gene	ChrX:131136636-131157548 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036553	protein coding gene	ChrX:134917176-134941172 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033381	protein coding gene	ChrX:122686097-122710528 (+)
CAST/EiJ	MGP_CASTEiJ_G0035022	protein coding gene	ChrX:112012691-112035716 (+)
CBA/J	MGP_CBAJ_G0035712	protein coding gene	ChrX:138955091-138977833 (+)
DBA/2J	MGP_DBA2J_G0035865	protein coding gene	ChrX:129822059-129844799 (+)
FVB/NJ	MGP_FVBNJ_G0035807	protein coding gene	ChrX:129134376-129156841 (+)
LP/J	MGP_LPJ_G0035958	protein coding gene	ChrX:131931335-131954071 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035835	protein coding gene	ChrX:146352478-146375636 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036582	protein coding gene	ChrX:130484713-130507571 (+)
PWK/PhJ	MGP_PWKPhJ_G0034714	protein coding gene	ChrX:108968293-108992618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034546	protein coding gene	ChrX:112638245-112662434 (+)
WSB/EiJ	MGP_WSBEiJ_G0035159	protein coding gene	ChrX:128865653-128892555 (+)

Human Ortholog

SRPX2, sushi repeat containing protein X-linked 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRPX2, sushi repeat containing protein X-linked 2
Synonyms

BPP, CBPS, PMGX, RESDX, SRPUL
Links

HGNC:30668

NCBI Gene ID: 27286

neXtProt AC: NX_O60687

UniProt: O60687
Chr Location

Xq22.1; chrX:100644195-100675788 (+) GRCh38

MGI Vertebrate Homology

Srpx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRPX2
Gene Tree

Srpx2

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal vocalization and response to social novelty.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

18
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srpx2

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All Sequences

43
RefSeq

6
UniProt

1
CCDS

CCDS41119.2

Ensembl

ENSMUSG00000031253 (Evidence)
NCBI Gene

68792

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031253	Ensembl Gene Model \| MGI Sequence Detail	24021	C57BL/6J	± kb
transcript	ENSMUST00000113304	Ensembl \| MGI Sequence Detail	2848	Not Applicable
polypeptide	ENSMUSP00000108929	Ensembl \| MGI Sequence Detail	468	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015635 sushi repeat-containing protein SRPX2

(term hierarchy)
InterPro Domains

IPR025232 Domain of unknown function DUF4174

IPR003410 HYR domain

IPR043555 Sushi repeat-containing protein SRPX-like

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 20

cDNA 20

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srpx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161979	ChrX:132809167-132809179 (+)	-2 bp
Tssr161980	ChrX:132809190-132809211 (+)	26 bp
Tssr161981	ChrX:132809223-132809230 (+)	52 bp
Tssr161982	ChrX:132809355-132809383 (+)	194 bp
Tssr161983	ChrX:132809384-132809407 (+)	221 bp
Tssr161984	ChrX:132809416-132809458 (+)	262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24