Sync MGI Mouse Gene Detail - MGI:1916078

Symbol

Sync
Name

syncoilin
Synonyms

1110057H03Rik, SNIP4

Feature Type

protein coding gene
IDs

MGI:1916078
NCBI Gene: 68828
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:129181410-129202352 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.26 cM
Mapping Data

3 experiments

SNPs within 2kb

361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916078	protein coding gene	Chr4:129181066-129203175 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028818	protein coding gene	Chr4:131181998-131205859 (+)
A/J	MGP_AJ_G0028777	protein coding gene	Chr4:125961876-125983077 (+)
AKR/J	MGP_AKRJ_G0028730	protein coding gene	Chr4:129460378-129483890 (+)
BALB/cJ	MGP_BALBcJ_G0028800	protein coding gene	Chr4:126553048-126575198 (+)
C3H/HeJ	MGP_C3HHeJ_G0028514	protein coding gene	Chr4:129511909-129536672 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029242	protein coding gene	Chr4:136134061-136155361 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026515	protein coding gene	Chr4:119092182-119112538 (+)
CAST/EiJ	MGP_CASTEiJ_G0027947	protein coding gene	Chr4:127694976-127718601 (+)
CBA/J	MGP_CBAJ_G0028480	protein coding gene	Chr4:139444108-139468934 (+)
DBA/2J	MGP_DBA2J_G0028629	protein coding gene	Chr4:126392638-126413658 (+)
FVB/NJ	MGP_FVBNJ_G0028596	protein coding gene	Chr4:125154974-125175794 (+)
LP/J	MGP_LPJ_G0028730	protein coding gene	Chr4:131479276-131502588 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028622	protein coding gene	Chr4:144347001-144368598 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029280	protein coding gene	Chr4:129834710-129856604 (+)
PWK/PhJ	MGP_PWKPhJ_G0027668	protein coding gene	Chr4:122970232-122992057 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027495	protein coding gene	Chr4:125695383-125719304 (+)
WSB/EiJ	MGP_WSBEiJ_G0028027	protein coding gene	Chr4:129950344-129971955 (+)

Human Ortholog

SYNC, syncoilin, intermediate filament protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYNC, syncoilin, intermediate filament protein
Synonyms

SYNC1, SYNCOILIN
Links

HGNC:28897

NCBI Gene ID: 81493

neXtProt AC: NX_Q9H7C4

UniProt: Q9H7C4
Chr Location

1p35.1; chr1:32679906-32703596 (-) GRCh38

MGI Vertebrate Homology

Sync stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYNC
Gene Tree

Sync

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Sync
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for one knock-out allele show reduced generation of isometric stress in skeletal muscle but a normal response to eccentric contraction-induced injury. Homozygotes for another knock-out allele show impaired contractility and increased skeletalmuscle damage under a forced exercise regime.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

6
UniProt

4
CCDS

CCDS18687.1

Ensembl

ENSMUSG00000001333 (Evidence)
NCBI Gene

68828

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001333	Ensembl Gene Model \| MGI Sequence Detail	20943	C57BL/6J	± kb
transcript	ENSMUST00000102599	Ensembl \| MGI Sequence Detail	2042	Not Applicable
polypeptide	ENSMUSP00000099659	Ensembl \| MGI Sequence Detail	470	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015873 syncoilin

(term hierarchy)
InterPro Domains

IPR039008 Intermediate filament, rod domain

IPR027702 Syncoilin
GlyGen

Q9EPM5 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 7

Primer pair 2

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:268425 Li Z, et al., Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601

TSS for Sync:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39133	Chr4:129181407-129181437 (+)	12 bp
Tssr39134	Chr4:129181439-129181459 (+)	39 bp
Tssr39135	Chr4:129181466-129181478 (+)	62 bp
Tssr39136	Chr4:129181491-129181506 (+)	89 bp
Tssr39137	Chr4:129181515-129181531 (+)	113 bp
Tssr39138	Chr4:129202206-129202211 (+)	20,799 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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