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Foxk2 Gene Detail
Summary
  • Symbol
    Foxk2
  • Name
    forkhead box K2
  • Synonyms
    1110054H05Rik, 5730434B08Rik, Ilf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916087
    NCBI Gene: 68837
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121150816-121200722 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 85.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1004 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916087
 protein coding gene Chr11:121150805-121200726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019545
 protein coding gene Chr11:125820879-125853843 (+)
A/J MGP_AJ_G0019512
 protein coding gene Chr11:120178141-120232891 (+)
AKR/J MGP_AKRJ_G0019482
 protein coding gene Chr11:123820619-123872926 (+)
BALB/cJ MGP_BALBcJ_G0019487
 protein coding gene Chr11:120548575-120597712 (+)
C3H/HeJ MGP_C3HHeJ_G0019293
 protein coding gene Chr11:124144102-124201997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019936
 protein coding gene Chr11:129612380-129678586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017561
 protein coding gene Chr11:117162178-117212471 (+)
CAST/EiJ MGP_CASTEiJ_G0018847
 protein coding gene Chr11:125649228-125701241 (+)
CBA/J MGP_CBAJ_G0019264
 protein coding gene Chr11:134649284-134703236 (+)
DBA/2J MGP_DBA2J_G0019377
 protein coding gene Chr11:119549058-119602308 (+)
FVB/NJ MGP_FVBNJ_G0019368
 protein coding gene Chr11:119269684-119318941 (+)
LP/J MGP_LPJ_G0019448
 protein coding gene Chr11:126075122-126131632 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019401
 protein coding gene Chr11:133461437-133512806 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019975
 protein coding gene Chr11:124508511-124559882 (+)
PWK/PhJ MGP_PWKPhJ_G0018614
 protein coding gene Chr11:120993247-121043919 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018405
 protein coding gene Chr11:124259435-124309383 (+)
WSB/EiJ MGP_WSBEiJ_G0018900
 protein coding gene Chr11:124476154-124529855 (+)



Homology
more
  • Human Ortholog
    FOXK2, forkhead box K2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXK2, forkhead box K2
  • Synonyms
    ILF, ILF-1, ILF1, nGTBP
  • Links
    NCBI Gene ID: 3607
    neXtProt AC: NX_Q01167
    UniProt: Q01167

  • Chr Location
    17q25.3; chr17:82519713-82644662 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    168
  • cDNA Data
    145
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039275 Ensembl Gene Model | MGI Sequence Detail 49907 C57BL/6J ±  kb
    transcript ENSMUST00000106113 Ensembl | MGI Sequence Detail 5029 Not Applicable  
    polypeptide ENSMUSP00000101719 Ensembl | MGI Sequence Detail 651 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007632 forkhead box protein K2
      (term hierarchy)
    • InterPro Domains
      IPR000253 Forkhead-associated (FHA) domain
      IPR047398 Forkhead box protein K2, forkhead associated domain
      IPR047397 Forkhead box protein K2, forkhead domain
      IPR001766 Fork head domain
      IPR018122 Fork head domain conserved site1
      IPR030456 Fork head domain conserved site 2
      IPR008984 SMAD/FHA domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q3UCQ1 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 149
      Genomic 2
      cDNA 146
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1913885, MGI:891988
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:39656 Farrington SM, et al., Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech Dev. 1997 Mar;62(2):197-211
    • Latest
      J:358009 El-Mergawy R, et al., FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. J Biol Chem. 2024 Jun;300(6):107359
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory