Ctc1 MGI Mouse Gene Detail - MGI:1916214 - CTS telomere maintenance complex component 1

Symbol

Ctc1
Name

CTS telomere maintenance complex component 1
Synonyms

1500010J02Rik

Feature Type

protein coding gene
IDs

MGI:1916214
NCBI Gene: 68964
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:68906737-68927299 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.29 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

476 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916214	protein coding gene	Chr11:68906014-68927299 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018513	protein coding gene	Chr11:69413956-69435574 (+)
A/J	MGP_AJ_G0018482	protein coding gene	Chr11:66805648-66826930 (+)
AKR/J	MGP_AKRJ_G0018451	protein coding gene	Chr11:68802314-68825234 (+)
BALB/cJ	MGP_BALBcJ_G0018453	protein coding gene	Chr11:67128291-67148810 (+)
C3H/HeJ	MGP_C3HHeJ_G0018266	protein coding gene	Chr11:68824228-68846056 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018905	protein coding gene	Chr11:71523086-71550854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016549	protein coding gene	Chr11:63744992-63766933 (+)
CAST/EiJ	MGP_CASTEiJ_G0017822	protein coding gene	Chr11:69059927-69080401 (+)
CBA/J	MGP_CBAJ_G0018240	protein coding gene	Chr11:74715931-74756562 (+)
DBA/2J	MGP_DBA2J_G0018349	protein coding gene	Chr11:66406569-66427121 (+)
FVB/NJ	MGP_FVBNJ_G0018339	protein coding gene	Chr11:66022903-66043957 (+)
LP/J	MGP_LPJ_G0018420	protein coding gene	Chr11:70000909-70022294 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018362	protein coding gene	Chr11:75367825-75388885 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018946	protein coding gene	Chr11:69053282-69073741 (+)
PWK/PhJ	MGP_PWKPhJ_G0017597	protein coding gene	Chr11:67039470-67060794 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017385	protein coding gene	Chr11:68884385-68906013 (+)
WSB/EiJ	MGP_WSBEiJ_G0017875	protein coding gene	Chr11:68693777-68717023 (+)

Human Ortholog

CTC1, CST telomere replication complex component 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTC1, CST telomere replication complex component 1
Synonyms

AAF-132, AAF132, C17orf68, CRMCC, tmp494178
Links

HGNC:26169

NCBI Gene ID: 80169

neXtProt AC: NX_Q2NKJ3

UniProt: Q2NKJ3
Chr Location

17p13.1; chr17:8224815-8248058 (-) GRCh38

MGI Vertebrate Homology

Ctc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTC1
Gene Tree

Ctc1

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

58
Targeted

5
Genomic Mutations

1 involving Ctc1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit defective telomere replication that leads to stem cell exhaustion, bone marrow failure and premature death.

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All GO Annotations

36
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctc1

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All Sequences

118
RefSeq

22
UniProt

3
CCDS

CCDS36189.2, CCDS48824.1, CCDS70214.1

Ensembl

ENSMUSG00000020898 (Evidence)
NCBI Gene

68964

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020898	Ensembl Gene Model \| MGI Sequence Detail	20563	C57BL/6J	± kb
transcript	ENSMUST00000116359	Ensembl \| MGI Sequence Detail	3978	Not Applicable
polypeptide	ENSMUSP00000112063	Ensembl \| MGI Sequence Detail	1212	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031091 CST complex subunit CTC1

(term hierarchy)
InterPro Domains

IPR029156 CST complex subunit CTC1

IPR042617 CST complex subunit CTC1-like

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All nucleic 14

cDNA 14

Microarray probesets 8

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102355	Chr11:68906899-68906961 (+)	193 bp
Tssr102356	Chr11:68911731-68911734 (+)	4,996 bp
Tssr102357	Chr11:68916869-68916881 (+)	10,138 bp
Tssr102358	Chr11:68916892-68916911 (+)	10,165 bp
Tssr102359	Chr11:68917650-68917660 (+)	10,918 bp
Tssr102360	Chr11:68917914-68917949 (+)	11,195 bp
Tssr102361	Chr11:68918120-68918162 (+)	11,404 bp
Tssr102362	Chr11:68918166-68918185 (+)	11,439 bp
Tssr102363	Chr11:68918801-68918808 (+)	12,068 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24