Tnik MGI Mouse Gene Detail - MGI:1916264 - TRAF2 and NCK interacting kinase

Symbol

Tnik
Name

TRAF2 and NCK interacting kinase
Synonyms

1500031A17Rik, 4831440I19Rik, C530008O15Rik, C630040K21Rik

Feature Type

protein coding gene
IDs

MGI:1916264
NCBI Gene: 665113
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:28317362-28724734 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 11.92 cM
Mapping Data

2 experiments

SNPs within 2kb

11702 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916264	protein coding gene	Chr3:28317362-28730007 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027115	protein coding gene	Chr3:25642278-26067306 (+)
A/J	MGP_AJ_G0027075	protein coding gene	Chr3:25395212-25796262 (+)
AKR/J	MGP_AKRJ_G0027044	protein coding gene	Chr3:25750496-26171736 (+)
BALB/cJ	MGP_BALBcJ_G0027087	protein coding gene	Chr3:25078861-25501867 (+)
C3H/HeJ	MGP_C3HHeJ_G0026828	protein coding gene	Chr3:25784558-26214014 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027532	protein coding gene	Chr3:27023498-27456467 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024894	protein coding gene	Chr3:23407321-23813088 (+)
CAST/EiJ	MGP_CASTEiJ_G0026283	protein coding gene	Chr3:25650204-26065230 (+)
CBA/J	MGP_CBAJ_G0026806	protein coding gene	Chr3:27742151-28198276 (+)
DBA/2J	MGP_DBA2J_G0026940	protein coding gene	Chr3:24943742-25376361 (+)
FVB/NJ	MGP_FVBNJ_G0026908	protein coding gene	Chr3:24424284-24835191 (+)
LP/J	MGP_LPJ_G0027052	protein coding gene	Chr3:26319186-26761982 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026929	protein coding gene	Chr3:30306105-30749072 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027592	protein coding gene	Chr3:25490383-25916945 (+)
PWK/PhJ	MGP_PWKPhJ_G0026016	protein coding gene	Chr3:24435502-24855688 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025827	protein coding gene	Chr3:25014985-25442965 (+)
WSB/EiJ	MGP_WSBEiJ_G0026357	protein coding gene	Chr3:25540564-25965378 (+)

Human Ortholog

TNIK, TRAF2 and NCK interacting kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNIK, TRAF2 and NCK interacting kinase
Synonyms

MRT54
Links

HGNC:30765

NCBI Gene ID: 23043

neXtProt AC: NX_Q9UKE5

UniProt: Q9UKE5
Chr Location

3q26.2-q26.31; chr3:171058414-171460408 (-) GRCh38

MGI Vertebrate Homology

Tnik stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNIK
Gene Tree

Tnik

Diseases

1 with human TNIK associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 54 IDs autosomal recessive intellectual developmental disorder 54 DOID:0081216 OMIM:617028

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

7
Genomic Mutations

1 involving Tnik
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function.

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All GO Annotations

70
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnik

ZFIN tnika, tnikb

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All Sequences

114
RefSeq

23
UniProt

13
CCDS

CCDS50877.1, CCDS50878.1, CCDS50879.1

Ensembl

ENSMUSG00000027692 (Evidence)
NCBI Gene

665113

			Length	Strain/Species	Flank
genomic	665113	NCBI Gene Model \| MGI Sequence Detail	407373	C57BL/6J	± kb
transcript	NM_026910	RefSeq \| MGI Sequence Detail	7146	C57BL/6
polypeptide	P83510	UniProt \| EBI \| MGI Sequence Detail	1323	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000016491 TRAF2 and NCK-interacting protein kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR051700 STE20 Ser/Thr Protein Kinase
GlyGen

P83510 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (3 sites)

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All nucleic 25

cDNA 25

Microarray probesets 8

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MGI:1925958, MGI:2139720, MGI:2441673, MGI:2444917

Summaries

All 48

Developmental Gene Expression 1

Diseases 1

Gene Ontology 12

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnik:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28643	Chr3:28317354-28317363 (+)	-3 bp
Tssr28644	Chr3:28317380-28317482 (+)	69 bp
Tssr28645	Chr3:28317504-28317535 (+)	158 bp
Tssr28646	Chr3:28317545-28317562 (+)	192 bp
Tssr28647	Chr3:28317572-28317577 (+)	213 bp
Tssr28648	Chr3:28317581-28317586 (+)	222 bp
Tssr28649	Chr3:28317716-28317726 (+)	359 bp
Tssr28650	Chr3:28367454-28367458 (+)	50,094 bp
Tssr847	Chr3:28485678-28485681 (+)	168,318 bp
Tssr848	Chr3:28517828-28517831 (+)	200,468 bp
Tssr28651	Chr3:28613304-28613309 (+)	295,945 bp
Tssr849	Chr3:28635334-28635341 (+)	317,976 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24