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Slc30a5 Gene Detail
Summary
  • Symbol
    Slc30a5
  • Name
    solute carrier family 30 (zinc transporter), member 5
  • Synonyms
    1810010K08Rik, Znt5, ZnT-5, Zntl1, ZTL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916298
    NCBI Gene: 69048
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100939156-100969935 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.23 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    867 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916298
 protein coding gene Chr13:100939153-100969988 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020896
 protein coding gene Chr13:102741064-102777195 (-)
A/J MGP_AJ_G0020847
 protein coding gene Chr13:98751735-98783768 (-)
AKR/J MGP_AKRJ_G0020822
 protein coding gene Chr13:101775424-101808558 (-)
BALB/cJ MGP_BALBcJ_G0020847
 protein coding gene Chr13:99479543-99510296 (-)
C3H/HeJ MGP_C3HHeJ_G0020636
 protein coding gene Chr13:101492378-101524153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021281
 protein coding gene Chr13:105828194-105858901 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018851
 protein coding gene Chr13:94568363-94598986 (-)
CAST/EiJ MGP_CASTEiJ_G0020155
 protein coding gene Chr13:100958637-100995543 (-)
CBA/J MGP_CBAJ_G0020598
 protein coding gene Chr13:109985271-110018568 (-)
DBA/2J MGP_DBA2J_G0020722
 protein coding gene Chr13:98559485-98590696 (-)
FVB/NJ MGP_FVBNJ_G0020704
 protein coding gene Chr13:97270008-97304951 (-)
LP/J MGP_LPJ_G0020796
 protein coding gene Chr13:102795990-102828102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020732
 protein coding gene Chr13:110221087-110257714 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021320
 protein coding gene Chr13:101232721-101264584 (-)
PWK/PhJ MGP_PWKPhJ_G0019908
 protein coding gene Chr13:97266562-97298073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019730
 protein coding gene Chr13:97462804-97494005 (-)
WSB/EiJ MGP_WSBEiJ_G0020213
 protein coding gene Chr13:101707047-101738763 (-)



Homology
more
  • Human Ortholog
    SLC30A5, solute carrier family 30 member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC30A5, solute carrier family 30 member 5
  • Synonyms
    ZnT-5, ZNT5, ZNTL1, ZTL1
  • Links
    NCBI Gene ID: 64924
    neXtProt AC: NX_Q8TAD4
    UniProt: Q8TAD4

  • Chr Location
    5q13.1-q13.2; chr5:69093991-69131069 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are growth retarded and exhibit skeletal defects including reduced bone density. The majority of mutant male mice die suddenly when they reach reproductive age due to bradyarrhythmia, whereas female mice live a normal term.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    7
  • cDNA Data
    105
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021629 Ensembl Gene Model | MGI Sequence Detail 30780 C57BL/6J ±  kb
    transcript ENSMUST00000067246 Ensembl | MGI Sequence Detail 3179 Not Applicable  
    polypeptide ENSMUSP00000065764 Ensembl | MGI Sequence Detail 761 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 107
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2159353
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:76894 Lacourse KA, et al., Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999 May;276(5 Pt 1):G1302-9
    • Latest
      J:358278 Yang Y, et al., Erythrocytic alpha-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2024 Jan;39(1):40-52
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory