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Nat8f5 Gene Detail
Summary
  • Symbol
    Nat8f5
  • Name
    N-acetyltransferase 8 (GCN5-related) family member 5
  • Synonyms
    1810018F03Rik, Cml5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916299
    NCBI Gene: 69049
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85794200-85797954 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.48 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916299
 protein coding gene Chr6:85794200-85797954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030962
 protein coding gene Chr6:87042259-87046012 (-)
A/J MGP_AJ_G0030928
 protein coding gene Chr6:83695367-83699120 (-)
AKR/J MGP_AKRJ_G0030859
 protein coding gene Chr6:86120341-86124095 (-)
BALB/cJ MGP_BALBcJ_G0030941
 protein coding gene Chr6:83674366-83678120 (-)
C3H/HeJ MGP_C3HHeJ_G0030769
 protein coding gene Chr6:98326491-98330244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031398
 protein coding gene Chr6:89411791-89415545 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030050
 protein coding gene Chr6:86147097-86150849 (-)
CBA/J MGP_CBAJ_G0030625
 protein coding gene Chr6:92907704-92911457 (-)
DBA/2J MGP_DBA2J_G0030778
 protein coding gene Chr6:83001075-83004828 (-)
FVB/NJ MGP_FVBNJ_G0030734
 protein coding gene Chr6:82189423-82193176 (-)
LP/J MGP_LPJ_G0030860
 protein coding gene Chr6:87046596-87050349 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030767
 protein coding gene Chr6:97102684-97106437 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031425
 protein coding gene Chr6:85947296-85951048 (-)
PWK/PhJ MGP_PWKPhJ_G0029765
 protein coding gene Chr6:81938292-81942044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029593
 protein coding gene Chr6:84817525-84821262 (-)
WSB/EiJ MGP_WSBEiJ_G0030131
 protein coding gene Chr6:86400534-86404280 (-)



Homology
more
  • Human Ortholog
    NAT8, N-acetyltransferase 8 (putative)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAT8, N-acetyltransferase 8 (putative)
  • Synonyms
    ATase2, CCNAT, CML1, GLA, Hcml1, TSC501, TSC510
  • Links
    NCBI Gene ID: 9027
    neXtProt AC: NX_Q9UHE5
    UniProt: Q9UHE5

  • Chr Location
    2p13.1; chr2:73640723-73642422 (-)  GRCh38
  • Human Ortholog
    NAT8B, N-acetyltransferase 8B (putative, gene/pseudogene)
  • Synonyms
    CML2, Hcml2, NAT8BP
  • Links
    NCBI Gene ID: 51471
    neXtProt AC: NX_Q9UHF3
    UniProt: Q9UHF3

  • Chr Location
    2p13.1; chr2:73700509-73702125 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    12 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit complex congenital heart disease associated with heterotaxy, abdominal organ situs anomalies, omphalocele and gastroschisis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    14
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69049 NCBI Gene Model | MGI Sequence Detail 3755 C57BL/6J ±  kb
    transcript NM_023493 RefSeq | MGI Sequence Detail 986 C57BL/6  
    polypeptide Q9QXS8 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory