Sgsm3 MGI Mouse Gene Detail - MGI:1916329 - small G protein signaling modulator 3

Symbol

Sgsm3
Name

small G protein signaling modulator 3
Synonyms

1810012I01Rik, CIP85, Rutbc3

Feature Type

protein coding gene
IDs

MGI:1916329
NCBI Gene: 105835
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:80861966-80896491 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.96 cM
Mapping Data

2 experiments

SNPs within 2kb

796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916329	protein coding gene	Chr15:80861966-80896491 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022105	protein coding gene	Chr15:81370005-81413701 (+)
A/J	MGP_AJ_G0022066	protein coding gene	Chr15:78525051-78558990 (+)
AKR/J	MGP_AKRJ_G0022041	protein coding gene	Chr15:80718202-80751922 (+)
BALB/cJ	MGP_BALBcJ_G0022072	protein coding gene	Chr15:78530065-78569612 (+)
C3H/HeJ	MGP_C3HHeJ_G0021843	protein coding gene	Chr15:80704444-80740784 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022515	protein coding gene	Chr15:84555938-84595922 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020045	protein coding gene	Chr15:75001124-75035447 (+)
CAST/EiJ	MGP_CASTEiJ_G0021364	protein coding gene	Chr15:81453335-81489794 (+)
CBA/J	MGP_CBAJ_G0021808	protein coding gene	Chr15:87205597-87251557 (+)
DBA/2J	MGP_DBA2J_G0021937	protein coding gene	Chr15:78014223-78048937 (+)
FVB/NJ	MGP_FVBNJ_G0021915	protein coding gene	Chr15:77050631-77085124 (+)
LP/J	MGP_LPJ_G0022005	protein coding gene	Chr15:81534951-81571706 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021935	protein coding gene	Chr15:92194733-92234014 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022529	protein coding gene	Chr15:80766149-80804114 (+)
PWK/PhJ	MGP_PWKPhJ_G0021106	protein coding gene	Chr15:78031093-78068737 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020943	protein coding gene	Chr15:80561567-80596737 (+)
WSB/EiJ	MGP_WSBEiJ_G0021416	protein coding gene	Chr15:81170532-81208859 (+)

Human Ortholog

SGSM3, small G protein signaling modulator 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SGSM3, small G protein signaling modulator 3
Synonyms

CIP85, MAP, RabGAP-5, RABGAP5, rabGAPLP, RUSC3, RUTBC3
Links

HGNC:25228

NCBI Gene ID: 27352

neXtProt AC: NX_Q96HU1

UniProt: Q96HU1
Chr Location

22q13.1; chr22:40370591-40410289 (+) GRCh38

MGI Vertebrate Homology

Sgsm3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SGSM3
Gene Tree

Sgsm3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Sgsm3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

25
cDNA Data

91
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sgsm3

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All Sequences

96
RefSeq

20
UniProt

8
CCDS

CCDS49673.2

Ensembl

ENSMUSG00000042303 (Evidence)
NCBI Gene

105835

			Length	Strain/Species	Flank
genomic	105835	NCBI Gene Model \| MGI Sequence Detail	34526	C57BL/6J	± kb
transcript	NM_134091	RefSeq \| MGI Sequence Detail	3013	C57BL/6
polypeptide	Q8VCZ6	UniProt \| EBI \| MGI Sequence Detail	750	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014806 small G protein signaling modulator 3

(term hierarchy)
PDB

2YUO
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR050302 Rab GTPase-activating TBC domain-containing protein

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR035833 SGSM3, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR050670 Signal Transducing Adapter Molecule
GlyGen

Q8VCZ6 1 site, 1 N-linked glycan (1 site)

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All nucleic 93

cDNA 91

Primer pair 2

Microarray probesets 3

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MGI:2146003, MGI:2146266, MGI:2146321

Summaries

All 57

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sgsm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132255	Chr15:80861809-80861820 (+)	-151 bp
Tssr132256	Chr15:80861981-80862046 (+)	48 bp
Tssr132257	Chr15:80862074-80862077 (+)	110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24