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Tmem176b Gene Detail
Summary
  • Symbol
    Tmem176b
  • Name
    transmembrane protein 176B
  • Synonyms
    1810009M01Rik, Clast1, Lr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916348
    NCBI Gene: 65963
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48810745-48818363 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916348
 protein coding gene Chr6:48810745-48818430 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030713
 protein coding gene Chr6:47803540-47810981 (-)
A/J MGP_AJ_G0030684
 protein coding gene Chr6:45623955-45631406 (-)
AKR/J MGP_AKRJ_G0030609
 protein coding gene Chr6:47234539-47242216 (-)
BALB/cJ MGP_BALBcJ_G0030694
 protein coding gene Chr6:45959743-45967420 (-)
C3H/HeJ MGP_C3HHeJ_G0030407
 protein coding gene Chr6:47239698-47247375 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031149
 protein coding gene Chr6:48938593-48946274 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028356
 protein coding gene Chr6:43245009-43253280 (-)
CAST/EiJ MGP_CASTEiJ_G0029811
 protein coding gene Chr6:46956390-46964059 (-)
CBA/J MGP_CBAJ_G0030382
 protein coding gene Chr6:50946444-50954127 (-)
DBA/2J MGP_DBA2J_G0030531
 protein coding gene Chr6:45540717-45548395 (-)
FVB/NJ MGP_FVBNJ_G0030483
 protein coding gene Chr6:45177796-45185457 (-)
LP/J MGP_LPJ_G0030616
 protein coding gene Chr6:47789179-47796847 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030517
 protein coding gene Chr6:53752633-53760080 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031178
 protein coding gene Chr6:47097168-47104609 (-)
PWK/PhJ MGP_PWKPhJ_G0029523
 protein coding gene Chr6:45072731-45080393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029359
 protein coding gene Chr6:46450131-46457854 (-)
WSB/EiJ MGP_WSBEiJ_G0029888
 protein coding gene Chr6:47096155-47103607 (-)



Homology
more
  • Human Ortholog
    TMEM176B, transmembrane protein 176B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM176B, transmembrane protein 176B
  • Synonyms
    LR8, MS4B2
  • Links
    NCBI Gene ID: 28959
    neXtProt AC: NX_Q3YBM2
    UniProt: Q3YBM2

  • Chr Location
    7q36.1; chr7:150791285-150801360 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele exhibit severe sporadic ataxia and a small cerebellum associated with abnormal cerebellar lobulation, loss of the internal granule cell layer, poor formation of the external germinal layer, and disorganized Purkinje cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    883
  • Tissues
    131
  • cDNA Data
    266
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65963 NCBI Gene Model | MGI Sequence Detail 7619 C57BL/6J ±  kb
    transcript NM_023056 RefSeq | MGI Sequence Detail 1670 ZRU/MplStud  
    polypeptide Q9R1Q6 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 274
      Genomic 1
      cDNA 268
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 9
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:71873 Lurton J, et al., Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Am J Respir Cell Mol Biol. 1999 Feb;20(2):327-31
    • Latest
      J:338289 Jiang L, et al., A Potential Diagnostic and Prognostic Biomarker TMEM176B and Its Relationship With Immune Infiltration in Skin Cutaneous Melanoma. Front Cell Dev Biol. 2022;10:859958
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory