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Cgrrf1 Gene Detail
Summary
  • Symbol
    Cgrrf1
  • Name
    cell growth regulator with ring finger domain 1
  • Synonyms
    1110038G02Rik, 1810009H17Rik, CGR19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916368
    NCBI Gene: 68755
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:47069591-47091655 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.34 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916368
 protein coding gene Chr14:47069582-47091655 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021216
 protein coding gene Chr14:40523884-40545871 (+)
A/J MGP_AJ_G0021163
 protein coding gene Chr14:39315417-39337292 (+)
AKR/J MGP_AKRJ_G0021141
 protein coding gene Chr14:40838019-40868715 (+)
BALB/cJ MGP_BALBcJ_G0021167
 protein coding gene Chr14:39359586-39385441 (+)
C3H/HeJ MGP_C3HHeJ_G0020950
 protein coding gene Chr14:40625136-40646915 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021601
 protein coding gene Chr14:42270426-42295907 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019160
 protein coding gene Chr14:38677960-38702127 (+)
CAST/EiJ MGP_CASTEiJ_G0020475
 protein coding gene Chr14:37756465-37779642 (+)
CBA/J MGP_CBAJ_G0020916
 protein coding gene Chr14:43608607-43630570 (+)
DBA/2J MGP_DBA2J_G0021039
 protein coding gene Chr14:39214312-39236302 (+)
FVB/NJ MGP_FVBNJ_G0021024
 protein coding gene Chr14:38944543-38966844 (+)
LP/J MGP_LPJ_G0021109
 protein coding gene Chr14:40812382-40836422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021049
 protein coding gene Chr14:42974989-42999753 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021634
 protein coding gene Chr14:40382353-40404400 (+)
PWK/PhJ MGP_PWKPhJ_G0020224
 protein coding gene Chr14:36086982-36109340 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020048
 protein coding gene Chr14:36513241-36535110 (+)
WSB/EiJ MGP_WSBEiJ_G0020531
 protein coding gene Chr14:40489284-40512995 (+)



Homology
more
  • Human Ortholog
    CGRRF1, cell growth regulator with ring finger domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CGRRF1, cell growth regulator with ring finger domain 1
  • Synonyms
    CGR19, RNF197
  • Links
    NCBI Gene ID: 10668
    neXtProt AC: NX_Q99675
    UniProt: Q99675

  • Chr Location
    14q22.2; chr14:54509812-54539292 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    51
  • cDNA Data
    39
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68755 NCBI Gene Model | MGI Sequence Detail 22065 C57BL/6J ±  kb
    transcript NM_026832 RefSeq | MGI Sequence Detail 1320 C57BL/6  
    polypeptide Q8BMJ7 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005396 cell growth regulator with RING finger domain protein 1
      (term hierarchy)
    • InterPro Domains
      IPR042496 Cell growth regulator with RING finger domain protein 1
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR001841 Zinc finger, RING-type
    • GlyGen
      Q8BMJ7 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1916005
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory