Cnot8 MGI Mouse Gene Detail - MGI:1916375 - CCR4-NOT transcription complex, subunit 8

Symbol

Cnot8
Name

CCR4-NOT transcription complex, subunit 8
Synonyms

1500015I04Rik, 1810022F04Rik

Feature Type

protein coding gene
IDs

MGI:1916375
NCBI Gene: 69125
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:57994979-58009420 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 35.69 cM
Mapping Data

2 experiments

SNPs within 2kb

364 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916375	protein coding gene	Chr11:57983620-58009423 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018342	protein coding gene	Chr11:57773939-57789871 (+)
A/J	MGP_AJ_G0018312	protein coding gene	Chr11:55579592-55599561 (+)
AKR/J	MGP_AKRJ_G0018281	protein coding gene	Chr11:57417449-57431970 (+)
BALB/cJ	MGP_BALBcJ_G0018283	protein coding gene	Chr11:55930184-55946228 (+)
C3H/HeJ	MGP_C3HHeJ_G0018094	protein coding gene	Chr11:57341082-57356222 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018734	protein coding gene	Chr11:59544161-59561508 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016384	protein coding gene	Chr11:52939865-52954455 (+)
CAST/EiJ	MGP_CASTEiJ_G0017659	protein coding gene	Chr11:57441467-57459414 (+)
CBA/J	MGP_CBAJ_G0018069	protein coding gene	Chr11:62296397-62315720 (+)
DBA/2J	MGP_DBA2J_G0018178	protein coding gene	Chr11:55236672-55251451 (+)
FVB/NJ	MGP_FVBNJ_G0018169	protein coding gene	Chr11:54933649-54948819 (+)
LP/J	MGP_LPJ_G0018253	protein coding gene	Chr11:58312922-58328654 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018195	protein coding gene	Chr11:63420268-63435726 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018777	protein coding gene	Chr11:57440817-57460868 (+)
PWK/PhJ	MGP_PWKPhJ_G0017431	protein coding gene	Chr11:55838540-55853906 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017226	protein coding gene	Chr11:57336734-57349653 (+)
WSB/EiJ	MGP_WSBEiJ_G0017706	protein coding gene	Chr11:57091367-57106890 (+)

Human Ortholog

CNOT8, CCR4-NOT transcription complex subunit 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNOT8, CCR4-NOT transcription complex subunit 8
Synonyms

CAF1, Caf1b, CALIF, hCAF1, POP2
Links

HGNC:9207

NCBI Gene ID: 9337

neXtProt AC: NX_Q9UFF9

UniProt: Q9UFF9
Chr Location

5q33.2; chr5:154857553-154876792 (+) GRCh38

MGI Vertebrate Homology

Cnot8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNOT8
Gene Tree

Cnot8

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

35
Targeted

5
Genomic Mutations

1 involving Cnot8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a null allele exhibit lethality prior to E10.5.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

48
cDNA Data

176
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnot8

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All Sequences

64
RefSeq

14
UniProt

2
CCDS

CCDS24722.1

Ensembl

ENSMUSG00000020515 (Evidence)
NCBI Gene

69125

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020515	Ensembl Gene Model \| MGI Sequence Detail	14442	C57BL/6J	± kb
transcript	ENSMUST00000020822	Ensembl \| MGI Sequence Detail	2035	Not Applicable
polypeptide	ENSMUSP00000020822	Ensembl \| MGI Sequence Detail	292	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005656 CCR4-NOT transcription complex subunit 8

(term hierarchy)
EC

3.1.13.4
InterPro Domains

IPR039637 CCR4-NOT transcription complex subunit 7/8/Pop2

IPR006941 Ribonuclease CAF1

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

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All nucleic 178

cDNA 176

Primer pair 2

Microarray probesets 4

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MGI:1923593, MGI:2142427, MGI:2144376, MGI:2144436

Summaries

All 51

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:343009 Soeda S, et al., The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs. Development. 2023 Nov 1;150(21):dev201773

TSS for Cnot8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101674	Chr11:57993608-57993640 (+)	-1,355 bp
Tssr101675	Chr11:57993688-57993700 (+)	-1,285 bp
Tssr101676	Chr11:57993732-57993743 (+)	-1,241 bp
Tssr101677	Chr11:57994796-57994853 (+)	-154 bp
Tssr101678	Chr11:57994857-57994876 (+)	-112 bp
Tssr101679	Chr11:57994877-57994907 (+)	-87 bp
Tssr101680	Chr11:57994908-57994963 (+)	-43 bp
Tssr101681	Chr11:57994964-57995017 (+)	12 bp
Tssr101682	Chr11:57995065-57995106 (+)	107 bp
Tssr101683	Chr11:58008552-58008576 (+)	13,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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