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Slirp Gene Detail
Summary
  • Symbol
    Slirp
  • Name
    SRA stem-loop interacting RNA binding protein
  • Synonyms
    1810035L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916394
    NCBI Gene: 380773
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:87490666-87496694 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.67 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916394
 protein coding gene Chr12:87490666-87498976 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019988
 protein coding gene Chr12:88361462-88367466 (+)
A/J MGP_AJ_G0019946
 protein coding gene Chr12:84997019-85003029 (+)
AKR/J MGP_AKRJ_G0019921
 protein coding gene Chr12:87299643-87305650 (+)
BALB/cJ MGP_BALBcJ_G0019925
 protein coding gene Chr12:85337594-85343611 (+)
C3H/HeJ MGP_C3HHeJ_G0019731
 protein coding gene Chr12:87791902-87800206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020377
 protein coding gene Chr12:90897910-90903922 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017995
 protein coding gene Chr12:81878672-81887278 (+)
CAST/EiJ MGP_CASTEiJ_G0019281
 protein coding gene Chr12:82838755-82844730 (+)
CBA/J MGP_CBAJ_G0019703
 protein coding gene Chr12:94357585-94365894 (+)
DBA/2J MGP_DBA2J_G0019816
 protein coding gene Chr12:84498714-84504762 (+)
FVB/NJ MGP_FVBNJ_G0019803
 protein coding gene Chr12:83486990-83493027 (+)
LP/J MGP_LPJ_G0019890
 protein coding gene Chr12:88231054-88237061 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019842
 protein coding gene Chr12:97138196-97144233 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020409
 protein coding gene Chr12:86931787-86937796 (+)
PWK/PhJ MGP_PWKPhJ_G0019045
 protein coding gene Chr12:79055237-79062163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018840
 protein coding gene Chr12:81441410-81447620 (+)
WSB/EiJ MGP_WSBEiJ_G0019334
 protein coding gene Chr12:87711514-87717536 (+)



Homology
more
  • Human Ortholog
    SLIRP, SRA stem-loop interacting RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLIRP, SRA stem-loop interacting RNA binding protein
  • Synonyms
    C14orf156, DC50, PD04872
  • Links
    NCBI Gene ID: 81892
    neXtProt AC: NX_Q9GZT3
    UniProt: Q9GZT3

  • Chr Location
    14q24.3; chr14:77708071-77761104 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in partial preweaning lethality and reduced male fertility characterized by asthenozoospermia and abnormal sperm annulus and sperm mitochondrial sheath morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380773 NCBI Gene Model | MGI Sequence Detail 6029 C57BL/6J ±  kb
    transcript NM_026958 RefSeq | MGI Sequence Detail 427 Not Specified  
    polypeptide Q9D8T7 UniProt | EBI | MGI Sequence Detail 112 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015233 SRA stem-loop-interacting RNA-binding protein, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR052462 Glycine-rich RNA-binding
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR034152 SLIRP, RNA recognition motif
    • GlyGen
      Q9D8T7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:332011 Gineste C, et al., Enzymatically dissociated muscle fibers display rapid dedifferentiation and impaired mitochondrial calcium control. iScience. 2022 Dec 22;25(12):105654
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory