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Sec31a Gene Detail
Summary
  • Symbol
    Sec31a
  • Name
    SEC31 homolog A, COPII coat complex component
  • Synonyms
    1810024J13Rik, Sec31l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916412
    NCBI Gene: 69162
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100509508-100564093 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.48 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1470 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916412
 protein coding gene Chr5:100509508-100564132 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029785
 protein coding gene Chr5:101841027-101897032 (-)
A/J MGP_AJ_G0029751
 protein coding gene Chr5:98051866-98106436 (-)
AKR/J MGP_AKRJ_G0029697
 protein coding gene Chr5:101283763-101338331 (-)
BALB/cJ MGP_BALBcJ_G0029761
 protein coding gene Chr5:99080557-99135857 (-)
C3H/HeJ MGP_C3HHeJ_G0029484
 protein coding gene Chr5:101633254-101688265 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030216
 protein coding gene Chr5:106075392-106129969 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027451
 protein coding gene Chr5:93286451-93343145 (-)
CAST/EiJ MGP_CASTEiJ_G0028895
 protein coding gene Chr5:100281114-100337708 (-)
CBA/J MGP_CBAJ_G0029454
 protein coding gene Chr5:109759935-109814492 (-)
DBA/2J MGP_DBA2J_G0029598
 protein coding gene Chr5:98240461-98295232 (-)
FVB/NJ MGP_FVBNJ_G0029557
 protein coding gene Chr5:97046117-97101014 (-)
LP/J MGP_LPJ_G0029686
 protein coding gene Chr5:102457985-102512506 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029586
 protein coding gene Chr5:114840309-114896032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030249
 protein coding gene Chr5:100764628-100819189 (-)
PWK/PhJ MGP_PWKPhJ_G0028613
 protein coding gene Chr5:96670718-96727024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028448
 protein coding gene Chr5:98426117-98481824 (-)
WSB/EiJ MGP_WSBEiJ_G0028973
 protein coding gene Chr5:101097337-101153550 (-)



Homology
more
  • Human Ortholog
    SEC31A, SEC31 homolog A, COPII coat complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC31A, SEC31 homolog A, COPII coat complex component
  • Synonyms
    ABP125, ABP130, HPBKS, HSPC275, HSPC334, NEDSOSB, SEC31L1
  • Links
    NCBI Gene ID: 22872
    neXtProt AC: NX_O94979
    UniProt: O94979

  • Chr Location
    4q21.22; chr4:82818509-82901166 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEC31A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    176
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035325 Ensembl Gene Model | MGI Sequence Detail 54586 C57BL/6J ±  kb
    transcript ENSMUST00000094578 Ensembl | MGI Sequence Detail 4228 Not Applicable  
    polypeptide ENSMUSP00000092157 Ensembl | MGI Sequence Detail 1230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000014593 protein transport protein Sec31A
      (term hierarchy)
    • InterPro Domains
      IPR024298 Ancestral coatomer element 1, Sec16/Sec31
      IPR040251 Protein transport protein SEC31-like
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q3UPL0 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 2
      cDNA 176

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141084
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:351615 Tobias ES, et al., SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine. 2024 May;84(2):345-349
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory