Cd209b MGI Mouse Gene Detail - MGI:1916415

Symbol

Cd209b
Name

CD209b antigen
Synonyms

1810030I22Rik, mSIGNR1, SIGNR1

Feature Type

protein coding gene
IDs

MGI:1916415
NCBI Gene: 69165
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:3967655-3976841 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 1.92 cM, cytoband A1.2-A1.3
Mapping Data

4 experiments

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916415	protein coding gene	Chr8:3967655-3976844 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033321	protein coding gene	Chr8:889134-898349 (-)
A/J	MGP_AJ_G0033304	protein coding gene	Chr8:835367-844549 (-)
AKR/J	MGP_AKRJ_G0033235	protein coding gene	Chr8:871401-880585 (-)
BALB/cJ	MGP_BALBcJ_G0033304	protein coding gene	Chr8:893853-903018 (-)
C3H/HeJ	MGP_C3HHeJ_G0033018	protein coding gene	Chr8:879258-888442 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033814	protein coding gene	Chr8:924856-934040 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030786	protein coding gene	Chr8:765272-774419 (-)
CAST/EiJ	MGP_CASTEiJ_G0032341	protein coding gene	Chr8:795074-804229 (-)
CBA/J	MGP_CBAJ_G0032991	protein coding gene	Chr8:953421-962605 (-)
DBA/2J	MGP_DBA2J_G0033145	protein coding gene	Chr8:799211-808395 (-)
FVB/NJ	MGP_FVBNJ_G0033092	protein coding gene	Chr8:850594-859787 (-)
LP/J	MGP_LPJ_G0033237	protein coding gene	Chr8:837759-846941 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033127	protein coding gene	Chr8:922034-931202 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033832	protein coding gene	Chr8:854804-863999 (-)
PWK/PhJ	MGP_PWKPhJ_G0032051	protein coding gene	Chr8:792572-801883 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031895	protein coding gene	Chr8:811037-820210 (-)
WSB/EiJ	MGP_WSBEiJ_G0032454	protein coding gene	Chr8:841365-850568 (-)

Human Ortholog

CD209, CD209 molecule

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD209, CD209 molecule
Synonyms

CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN
Links

HGNC:1641

NCBI Gene ID: 30835

neXtProt AC: NX_Q9NNX6

UniProt: Q9NNX6
Chr Location

19p13.2; chr19:7739993-7747564 (-) GRCh38

Human Ortholog

CLEC4M, C-type lectin domain family 4 member M
Synonyms

CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
Links

HGNC:13523

NCBI Gene ID: 10332

neXtProt AC: NX_Q9H2X3

UniProt: Q9H2X3
Chr Location

19p13.2; chr19:7763210-7769605 (+) GRCh38

MGI Vertebrate Homology

Cd209b stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD209, CLEC4M
Gene Tree

Cd209b

Diseases

10 with human CD209,CLEC4M associations

				Human Disease	Mouse Models
				acquired immunodeficiency syndrome IDs acquired immunodeficiency syndrome DOID:635 EFO:0000765 ICD10CM:B20 MESH:D000163 NCI:C2851 UMLS_CUI:C0001175
				aspergillosis IDs aspergillosis DOID:13564 ICD10CM:B44 ICD9CM:117.3 MESH:D001228 NCI:C2886 UMLS_CUI:C0004030
				Coronavirus infectious disease IDs Coronavirus infectious disease DOID:0080599
				dengue disease IDs dengue disease DOID:12205 DOID:0050142 ICD10CM:A90 ICD9CM:061 MESH:D003715 NCI:C34528 UMLS_CUI:C0011311
				dengue hemorrhagic fever IDs dengue hemorrhagic fever DOID:12206 ICD10CM:A91 MESH:D019595 NCI:C34683 UMLS_CUI:C0019100
				extrapulmonary tuberculosis IDs extrapulmonary tuberculosis DOID:0050598
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				severe acute respiratory syndrome IDs severe acute respiratory syndrome DOID:2945 ICD10CM:J12.81 ICD9CM:079.82 MESH:D045169 NCI:C85064 UMLS_CUI:C1175175
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 2 alleles in 6 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutants are more susceptible to S. pneumoniae infection and fail to clear the bacteria from the circulation. Marginal zone and peritoneal macrophages are impaired in recognizing the bacteria.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

67
RefSeq

9
UniProt

3
CCDS

CCDS22076.1, CCDS22077.1, CCDS72089.1

Ensembl

ENSMUSG00000065987 (Evidence)
NCBI Gene

69165

			Length	Strain/Species	Flank
genomic	69165	NCBI Gene Model \| MGI Sequence Detail	9187	C57BL/6J	± kb
transcript	NM_026972	RefSeq \| MGI Sequence Detail	2068	C57BL/6
polypeptide	Q8CJ91	UniProt \| EBI \| MGI Sequence Detail	325	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006172 CD209 molecule-like protein B

(term hierarchy)
PDB

3ZHG, 4C9F, 4CAJ
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR051004 Dendritic cell-specific ICAM-grabbing non-integrin domain-containing protein
GlyGen

Q8CJ91 3 sites

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All nucleic 17

Genomic 1

cDNA 16

Microarray probesets 4

Summaries

All 65

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 26
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335620 Seeling M, et al., Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1. Immunity. 2023 May 9;56(5):1046-1063.e7

TSS for Cd209b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80237	Chr8:3976807-3976838 (-)	18 bp
Tssr80236	Chr8:3968216-3968219 (-)	8,623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24