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Ppp1r12b Gene Detail
Summary
  • Symbol
    Ppp1r12b
  • Name
    protein phosphatase 1, regulatory subunit 12B
  • Synonyms
    1810037O03Rik, 9530009M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916417
    NCBI Gene: 329251
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134682396-134883680 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.24 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4923 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916417
 protein coding gene Chr1:134682396-134883699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016513
 protein coding gene Chr1:138458174-138679525 (-)
A/J MGP_AJ_G0016496
 protein coding gene Chr1:133233363-133441318 (-)
AKR/J MGP_AKRJ_G0016461
 protein coding gene Chr1:137210726-137420449 (-)
BALB/cJ MGP_BALBcJ_G0016456
 protein coding gene Chr1:133555656-133760150 (-)
C3H/HeJ MGP_C3HHeJ_G0016282
 protein coding gene Chr1:137299733-137511651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016917
 protein coding gene Chr1:143484934-143703952 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014628
 protein coding gene Chr1:126354680-126557454 (-)
CAST/EiJ MGP_CASTEiJ_G0015862
 protein coding gene Chr1:136362215-136582985 (-)
CBA/J MGP_CBAJ_G0016255
 protein coding gene Chr1:148430247-148653075 (-)
DBA/2J MGP_DBA2J_G0016361
 protein coding gene Chr1:132237669-132447023 (-)
FVB/NJ MGP_FVBNJ_G0016360
 protein coding gene Chr1:130875975-131082741 (-)
LP/J MGP_LPJ_G0016432
 protein coding gene Chr1:139714665-139925367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016385
 protein coding gene Chr1:154131816-154356816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016953
 protein coding gene Chr1:136944833-137158959 (-)
PWK/PhJ MGP_PWKPhJ_G0015648
 protein coding gene Chr1:131260872-131468789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015435
 protein coding gene Chr1:135908382-136126984 (-)
WSB/EiJ MGP_WSBEiJ_G0015925
 protein coding gene Chr1:136971828-137188141 (-)



Homology
more
  • Human Ortholog
    PPP1R12B, protein phosphatase 1 regulatory subunit 12B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R12B, protein phosphatase 1 regulatory subunit 12B
  • Synonyms
    MYPT2, PP1bp55
  • Links
    NCBI Gene ID: 4660
    neXtProt AC: NX_O60237
    UniProt: O60237

  • Chr Location
    1q32.1; chr1:202348699-202592706 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in adult cardiomyocytes display blunted cardiac hypertrophic response to pressure overload. Mice homozygous for a null allele on a C57BL/6N background display improved cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073557 Ensembl Gene Model | MGI Sequence Detail 201285 C57BL/6J ±  kb
    transcript ENSMUST00000168381 Ensembl | MGI Sequence Detail 3621 Not Applicable  
    polypeptide ENSMUSP00000131406 Ensembl | MGI Sequence Detail 992 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013108 protein phosphatase 1 regulatory subunit 12B
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR031775 cGMP-dependent protein kinase, interacting domain
      IPR051226 Protein Phosphatase 1 Regulatory Subunit
      IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
    • GlyGen
      Q8BG95 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 15

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:2138164, MGI:2444883
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346986 Lee E, et al., The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo. J Biol Chem. 2024 Jan 13;300(2):105652
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory