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Snx5 Gene Detail
Summary
  • Symbol
    Snx5
  • Name
    sorting nexin 5
  • Synonyms
    0910001N05Rik, 1810032P22Rik, D2Ertd52e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916428
    NCBI Gene: 69178
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:144092043-144112713 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 70.98 cM, cytoband H1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916428
 protein coding gene Chr2:144092043-144112826 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026581
 protein coding gene Chr2:148319317-148343527 (-)
A/J MGP_AJ_G0026545
 protein coding gene Chr2:142323002-142344226 (-)
AKR/J MGP_AKRJ_G0026519
 protein coding gene Chr2:146414706-146435453 (-)
BALB/cJ MGP_BALBcJ_G0026557
 protein coding gene Chr2:142771321-142792514 (-)
C3H/HeJ MGP_C3HHeJ_G0026300
 protein coding gene Chr2:146946866-146969501 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027002
 protein coding gene Chr2:152782419-152803033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024379
 protein coding gene Chr2:136506346-136526277 (-)
CAST/EiJ MGP_CASTEiJ_G0025761
 protein coding gene Chr2:147288331-147312564 (-)
CBA/J MGP_CBAJ_G0026280
 protein coding gene Chr2:158351272-158372331 (-)
DBA/2J MGP_DBA2J_G0026414
 protein coding gene Chr2:141612066-141632476 (-)
FVB/NJ MGP_FVBNJ_G0026378
 protein coding gene Chr2:140197211-140217818 (-)
LP/J MGP_LPJ_G0026518
 protein coding gene Chr2:148484908-148506066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026398
 protein coding gene Chr2:162552954-162574430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027057
 protein coding gene Chr2:146407771-146428733 (-)
PWK/PhJ MGP_PWKPhJ_G0025497
 protein coding gene Chr2:141266772-141287959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025298
 protein coding gene Chr2:145453295-145473734 (-)
WSB/EiJ MGP_WSBEiJ_G0025834
 protein coding gene Chr2:147424738-147445481 (-)



Homology
more
  • Human Ortholog
    SNX5, sorting nexin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX5, sorting nexin 5
  • Links
    NCBI Gene ID: 27131
    neXtProt AC: NX_Q9Y5X3
    UniProt: Q9Y5X3

  • Chr Location
    20p11.23; chr20:17941597-17968980 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit impaired alveolar epithelial differentiation of type I cells, respiratory failure and lethality during the perinatal and postnatal periods.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1060
  • Tissues
    88
  • cDNA Data
    27
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69178 NCBI Gene Model | MGI Sequence Detail 20671 C57BL/6J ±  kb
    transcript NM_001199188 RefSeq | MGI Sequence Detail 2399 ZRU/MplStud  
    polypeptide Q9D8U8 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1098741, MGI:1915657, MGI:2139178
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory