Gtpbp4 MGI Mouse Gene Detail - MGI:1916487

Symbol

Gtpbp4
Name

GTP binding protein 4
Synonyms

2610028C09Rik, Crfg, Nog1

Feature Type

protein coding gene
IDs

MGI:1916487
NCBI Gene: 69237
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:9016367-9046119 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 3.64 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

792 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916487	protein coding gene	Chr13:9016039-9046119 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020222	protein coding gene	Chr13:5595307-5619250 (-)
A/J	MGP_AJ_G0020178	protein coding gene	Chr13:5592103-5616299 (-)
AKR/J	MGP_AKRJ_G0020153	protein coding gene	Chr13:5649897-5674173 (-)
BALB/cJ	MGP_BALBcJ_G0020161	protein coding gene	Chr13:5590303-5614482 (-)
C3H/HeJ	MGP_C3HHeJ_G0019965	protein coding gene	Chr13:5778004-5802871 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020608	protein coding gene	Chr13:5955267-5980201 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018215	protein coding gene	Chr13:5530164-5554559 (-)
CAST/EiJ	MGP_CASTEiJ_G0019503	protein coding gene	Chr13:5488390-5514180 (-)
CBA/J	MGP_CBAJ_G0019932	protein coding gene	Chr13:6075152-6109285 (-)
DBA/2J	MGP_DBA2J_G0020049	protein coding gene	Chr13:5422596-5447973 (-)
FVB/NJ	MGP_FVBNJ_G0020034	protein coding gene	Chr13:5278447-5304424 (-)
LP/J	MGP_LPJ_G0020123	protein coding gene	Chr13:5701956-5726098 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020070	protein coding gene	Chr13:6404516-6428864 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020636	protein coding gene	Chr13:5603623-5627655 (-)
PWK/PhJ	MGP_PWKPhJ_G0019266	protein coding gene	Chr13:5441586-5469658 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019073	protein coding gene	Chr13:5605394-5633936 (-)
WSB/EiJ	MGP_WSBEiJ_G0019563	protein coding gene	Chr13:5511454-5538269 (-)

Human Ortholog

GTPBP4, GTP binding protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTPBP4, GTP binding protein 4
Synonyms

CRFG, NGB, NOG1
Links

HGNC:21535

NCBI Gene ID: 23560

neXtProt AC: NX_Q9BZE4

UniProt: Q9BZE4
Chr Location

10p15.3; chr10:988434-1019932 (+) GRCh38

MGI Vertebrate Homology

Gtpbp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GTPBP4
Protein SuperFamily

NOG1
Gene Tree

Gtpbp4

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

46
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GTPBP4

Xenbase gtpbp4

ZFIN gtpbp4

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All Sequences

61
RefSeq

14
UniProt

5
CCDS

CCDS26236.1

Ensembl

ENSMUSG00000021149 (Evidence)
NCBI Gene

69237

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021149	Ensembl Gene Model \| MGI Sequence Detail	29753	C57BL/6J	± kb
transcript	ENSMUST00000222098	Ensembl \| MGI Sequence Detail	8783	Not Applicable
polypeptide	ENSMUSP00000152412	Ensembl \| MGI Sequence Detail	634	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008336 GTP-binding protein 4

(term hierarchy)
InterPro Domains

IPR006073 GTP binding domain

IPR041623 NOG1, N-terminal helical domain

IPR012973 NOG, C-terminal

IPR024926 Nucleolar GTP-binding protein 1

IPR010674 Nucleolar GTP-binding protein 1, Rossman-fold domain

IPR031167 OBG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR005225 Small GTP-binding protein domain

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All nucleic 12

cDNA 12

Microarray probesets 5

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MGI:1927543

Summaries

All 43

Gene Ontology 6

Phenotypes 13
Earliest

J:64988 Burmester T, et al., A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gtpbp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121350	Chr13:9046093-9046104 (-)	20 bp
Tssr121349	Chr13:9046040-9046088 (-)	55 bp
Tssr121348	Chr13:9030001-9030020 (-)	16,108 bp
Tssr121347	Chr13:9027413-9027426 (-)	18,699 bp
Tssr121346	Chr13:9024562-9024567 (-)	21,554 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24