Gins1 MGI Mouse Gene Detail - MGI:1916520

Symbol

Gins1
Name

GINS complex subunit 1
Synonyms

2810418N01Rik, Psf1

Feature Type

protein coding gene
IDs

MGI:1916520
NCBI Gene: 69270
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:150751482-150773200 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.75 cM, cytoband H1
Mapping Data

2 experiments

SNPs within 2kb

644 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916520	protein coding gene	Chr2:150747320-150773200 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026633	protein coding gene	Chr2:155350981-155381232 (+)
A/J	MGP_AJ_G0026600	protein coding gene	Chr2:149105638-149132157 (+)
AKR/J	MGP_AKRJ_G0026571	protein coding gene	Chr2:153432880-153461214 (+)
BALB/cJ	MGP_BALBcJ_G0026610	protein coding gene	Chr2:149539060-149569293 (+)
C3H/HeJ	MGP_C3HHeJ_G0026353	protein coding gene	Chr2:153864350-153893793 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027058	protein coding gene	Chr2:159896456-159923985 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024430	protein coding gene	Chr2:142974734-143001464 (+)
CAST/EiJ	MGP_CASTEiJ_G0025813	protein coding gene	Chr2:154119385-154144903 (+)
CBA/J	MGP_CBAJ_G0026332	protein coding gene	Chr2:165751351-165785951 (+)
DBA/2J	MGP_DBA2J_G0026466	protein coding gene	Chr2:148352841-148378415 (+)
FVB/NJ	MGP_FVBNJ_G0026431	protein coding gene	Chr2:146809013-146834771 (+)
LP/J	MGP_LPJ_G0026570	protein coding gene	Chr2:155496255-155526562 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026453	protein coding gene	Chr2:169858647-169891141 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027113	protein coding gene	Chr2:153364994-153394663 (+)
PWK/PhJ	MGP_PWKPhJ_G0025548	protein coding gene	Chr2:147979761-148006997 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025350	protein coding gene	Chr2:152297060-152325637 (+)
WSB/EiJ	MGP_WSBEiJ_G0025886	protein coding gene	Chr2:154329998-154357684 (+)

Human Ortholog

GINS1, GINS complex subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GINS1, GINS complex subunit 1
Synonyms

IMD55, PSF1
Links

HGNC:28980

NCBI Gene ID: 9837

neXtProt AC: NX_Q14691

UniProt: Q14691
Chr Location

20p11.21; chr20:25391008-25452700 (+) GRCh38

MGI Vertebrate Homology

Gins1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GINS1
Gene Tree

Gins1

Diseases

1 with human GINS1 associations

				Human Disease	Mouse Models
				immunodeficiency 55 IDs immunodeficiency 55 DOID:0111993 OMIM:617827 ORDO:505227

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

17
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Gins1
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out allele display disorganized embryonic and extraembryonic structures and fail to develop past E5.5; mutant blastocysts fail to exhibit outgrowth in culture and show a cell proliferation defect and inner cell mass apoptosis.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

108
cDNA Data

38
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gins1

ZFIN gins1

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS50743.1

Ensembl

ENSMUSG00000027454 (Evidence)
NCBI Gene

69270

			Length	Strain/Species	Flank
genomic	69270	NCBI Gene Model \| MGI Sequence Detail	21719	C57BL/6J	± kb
transcript	NM_027014	RefSeq \| MGI Sequence Detail	1100	C57BL/6
polypeptide	Q9CZ15	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007982 DNA replication complex GINS protein PSF1

(term hierarchy)
InterPro Domains

IPR005339 GINS complex, subunit Psf1

IPR036224 GINS, helical bundle-like domain superfamily

IPR021151 GINS subunit, domain A

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All nucleic 41

cDNA 38

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gins1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20711	Chr2:150751485-150751562 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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