Lelp1 Gene Detail

Summary

• Symbol
  Lelp1
• Name
  late cornified envelope-like proline-rich 1
• Synonyms
  1700012F11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1916582
  NCBI Gene: 69332
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:92042304-92050051 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM, cytoband F2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  241 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916582	protein coding gene	Chr3:92042301-92050061 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027487	protein coding gene	Chr3:92558450-92566283 (-)
A/J	MGP_AJ_G0027451	protein coding gene	Chr3:89604726-89612468 (-)
AKR/J	MGP_AKRJ_G0027416	protein coding gene	Chr3:91763268-91771016 (-)
BALB/cJ	MGP_BALBcJ_G0027460	protein coding gene	Chr3:89451361-89459123 (-)
C3H/HeJ	MGP_C3HHeJ_G0027202	protein coding gene	Chr3:91975365-91983112 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027906	protein coding gene	Chr3:96094448-96102244 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025257	protein coding gene	Chr3:86296704-86304454 (-)
CAST/EiJ	MGP_CASTEiJ_G0026647	protein coding gene	Chr3:91330500-91338298 (-)
CBA/J	MGP_CBAJ_G0027177	protein coding gene	Chr3:99379583-99387330 (-)
DBA/2J	MGP_DBA2J_G0027314	protein coding gene	Chr3:88971665-88979445 (-)
FVB/NJ	MGP_FVBNJ_G0027282	protein coding gene	Chr3:87144272-87152456 (-)
LP/J	MGP_LPJ_G0027423	protein coding gene	Chr3:93797998-93805749 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027303	protein coding gene	Chr3:105623832-105631557 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027965	protein coding gene	Chr3:91482543-91490312 (-)
PWK/PhJ	MGP_PWKPhJ_G0026381	protein coding gene	Chr3:88914393-88922202 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026199	protein coding gene	Chr3:89829799-89837228 (-)
WSB/EiJ	MGP_WSBEiJ_G0026729	protein coding gene	Chr3:91852398-91860254 (-)

Homology

• Human Ortholog
  LELP1, late cornified envelope like proline rich 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LELP1, late cornified envelope like proline rich 1
  
• Links
  HGNC:32046

  NCBI Gene ID: 149018

  neXtProt AC: NX_Q5T871

  UniProt: Q5T871

  
  
• Chr Location
  1q21.3; chr1:153203430-153205120 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lelp1 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: LELP1
• Gene Tree
  Lelp1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Lelp1
• Find Mice (IMSR)
  10 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice exhibit normal male fertility.

Expression

• Assay Results
  706
• cDNA Data
  1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS50974.1

• Ensembl
  ENSMUSG00000027927 (Evidence)
• NCBI Gene
  69332

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000027927	Ensembl Gene Model | MGI Sequence Detail	7748	C57BL/6J
transcript	ENSMUST00000029535	Ensembl | MGI Sequence Detail	857	Not Applicable
polypeptide	ENSMUSP00000029535	Ensembl | MGI Sequence Detail	120	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000009753 late cornified envelope-like proline-rich protein 1
  (term hierarchy)
• InterPro Domains
  IPR026076 Late cornified envelope-like proline-rich protein 1

Molecular
Reagents

• All nucleic 1

  cDNA 1

  
  

  Microarray probesets 3

References

• Summaries
  All 23

  Diseases 1

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:293870 Sun J, et al., CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction. Biol Reprod. 2020 Aug 4;103(2):183-194

TSS for Lelp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34272	Chr3:92050045-92050073 (-)	-8 bp