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Lrrc51 Gene Detail
Summary
  • Symbol
    Lrrc51
  • Name
    leucine rich repeat containing 51
  • Synonyms
    1700008D07Rik, Lrtomt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916608
    NCBI Gene: 69358
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101562191-101583102 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.69 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916608
protein coding gene Chr7:101562191-101583126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032594
protein coding gene Chr7:104930072-104954837 (-)
A/J MGP_AJ_G0032570
protein coding gene Chr7:102257623-102278495 (-)
AKR/J MGP_AKRJ_G0032506
protein coding gene Chr7:104703137-104726388 (-)
BALB/cJ MGP_BALBcJ_G0032581
protein coding gene Chr7:101955738-101976307 (-)
C3H/HeJ MGP_C3HHeJ_G0032295
protein coding gene Chr7:105077095-105098351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033078
protein coding gene Chr7:108882825-108916885 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030072
protein coding gene Chr7:104620203-104643301 (-)
CAST/EiJ MGP_CASTEiJ_G0031621
protein coding gene Chr7:96635052-96657083 (-)
CBA/J MGP_CBAJ_G0032261
protein coding gene Chr7:112657022-112680082 (-)
DBA/2J MGP_DBA2J_G0032413
protein coding gene Chr7:100588128-100609409 (-)
FVB/NJ MGP_FVBNJ_G0032369
protein coding gene Chr7:100369207-100390131 (-)
LP/J MGP_LPJ_G0032502
protein coding gene Chr7:106247890-106272393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032403
protein coding gene Chr7:113981787-114005291 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033100
protein coding gene Chr7:103974236-103998939 (-)
PWK/PhJ MGP_PWKPhJ_G0031339
protein coding gene Chr7:93699986-93721259 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031183
protein coding gene Chr7:91272106-91296200 (-)
WSB/EiJ MGP_WSBEiJ_G0031738
protein coding gene Chr7:104663913-104688077 (-)



Homology
more
  • Human Ortholog
    LRRC51, leucine rich repeat containing 51
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC51, leucine rich repeat containing 51
  • Links
    NCBI Gene ID: 120356739
    neXtProt AC: NX_Q96E66

  • Chr Location
    chr11:72080337-72096895 (+)  GRCh38

  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
  • Synonyms
    CFAP111, DFNB63, LRRC51, LRRC51-TOMT, TOMT
  • Links
    NCBI Gene ID: 220074
    neXtProt AC: NX_Q8WZ04, NX_Q96E66

  • Chr Location
    11q13.4; chr11:72080331-72110782 (+)  GRCh38

  • Human Ortholog
    TOMT, transmembrane O-methyltransferase
  • Synonyms
    COMT2
  • Links
    NCBI Gene ID: 120356740

  • Chr Location
    chr11:72105924-72109596 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LRTOMT associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064307 Ensembl Gene Model | MGI Sequence Detail 20912 C57BL/6J ±  kb
    transcript ENSMUST00000106968 Ensembl | MGI Sequence Detail 766 Not Applicable  
    polypeptide ENSMUSP00000102581 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory