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Glrx2 Gene Detail
Summary
  • Symbol
    Glrx2
  • Name
    glutaredoxin 2
  • Synonyms
    1700010P22Rik, Grx2, thioltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916617
    NCBI Gene: 69367
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143614787-143625416 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.53 cM, cytoband F
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916617
 protein coding gene Chr1:143592076-143625416 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016562
 protein coding gene Chr1:148067734-148105505 (+)
A/J MGP_AJ_G0016545
 protein coding gene Chr1:142164707-142197632 (+)
AKR/J MGP_AKRJ_G0016510
 protein coding gene Chr1:146528186-146562820 (+)
BALB/cJ MGP_BALBcJ_G0016505
 protein coding gene Chr1:142577684-142622178 (+)
C3H/HeJ MGP_C3HHeJ_G0016330
 protein coding gene Chr1:146636965-146680906 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016966
 protein coding gene Chr1:153064329-153098393 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014675
 protein coding gene Chr1:134978769-135010503 (+)
CAST/EiJ MGP_CASTEiJ_G0015909
 protein coding gene Chr1:146066107-146102084 (+)
CBA/J MGP_CBAJ_G0016304
 protein coding gene Chr1:158504867-158538258 (+)
DBA/2J MGP_DBA2J_G0016410
 protein coding gene Chr1:141262977-141295502 (+)
FVB/NJ MGP_FVBNJ_G0016408
 protein coding gene Chr1:139755958-139787179 (+)
LP/J MGP_LPJ_G0016481
 protein coding gene Chr1:149088455-149120122 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016434
 protein coding gene Chr1:164936230-164969694 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017002
 protein coding gene Chr1:146254364-146291938 (+)
PWK/PhJ MGP_PWKPhJ_G0015695
 protein coding gene Chr1:140171650-140207423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015482
 protein coding gene Chr1:145051133-145088514 (+)
WSB/EiJ MGP_WSBEiJ_G0015972
 protein coding gene Chr1:146293383-146329110 (+)



Homology
more
  • Human Ortholog
    GLRX2, glutaredoxin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRX2, glutaredoxin 2
  • Synonyms
    CGI-133, GRX2
  • Links
    NCBI Gene ID: 51022
    neXtProt AC: NX_Q9NS18
    UniProt: Q9NS18

  • Chr Location
    1q31.2; chr1:193090866-193106114 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to oxidative stress in primary mouse lens epithelial cells, and an increased level of glutathionylated proteins in mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69367 NCBI Gene Model | MGI Sequence Detail 10630 C57BL/6J ±  kb
    transcript NM_001038592 RefSeq | MGI Sequence Detail 3603 ZRU/MplStud  
    polypeptide Q923X4 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138305
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:74095 Kobayashi M, et al., Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Antioxid Redox Signal. 2000 Winter;2(4):653-63
    • Latest
      J:353938 Zhang J, et al., The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function. Exp Eye Res. 2023 Jun 3;233:109521
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory