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Pex5l Gene Detail
Summary
  • Symbol
    Pex5l
  • Name
    peroxisomal biogenesis factor 5-like
  • Synonyms
    1700016J08Rik, Pex2, PXR2, TRIP8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916672
    NCBI Gene: 58869
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:33003557-33197396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.94 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5529 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916672
 protein coding gene Chr3:33002075-33197470 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027145
 protein coding gene Chr3:30588725-30793474 (-)
A/J MGP_AJ_G0027105
 protein coding gene Chr3:30147822-30345003 (-)
AKR/J MGP_AKRJ_G0027074
 protein coding gene Chr3:30629994-30835190 (-)
BALB/cJ MGP_BALBcJ_G0027117
 protein coding gene Chr3:29789997-29986295 (-)
C3H/HeJ MGP_C3HHeJ_G0026860
 protein coding gene Chr3:30654802-30858527 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027563
 protein coding gene Chr3:32100114-32318893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024924
 protein coding gene Chr3:27935017-28134990 (-)
CAST/EiJ MGP_CASTEiJ_G0026313
 protein coding gene Chr3:30510090-30714547 (-)
CBA/J MGP_CBAJ_G0026837
 protein coding gene Chr3:32972121-33189466 (-)
DBA/2J MGP_DBA2J_G0026971
 protein coding gene Chr3:29609939-29805612 (-)
FVB/NJ MGP_FVBNJ_G0026939
 protein coding gene Chr3:29063401-29260489 (-)
LP/J MGP_LPJ_G0027083
 protein coding gene Chr3:31348422-31551872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026959
 protein coding gene Chr3:35455393-35659213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027622
 protein coding gene Chr3:30426711-30630418 (-)
PWK/PhJ MGP_PWKPhJ_G0026046
 protein coding gene Chr3:29148642-29347167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025858
 protein coding gene Chr3:29849038-30045705 (-)
WSB/EiJ MGP_WSBEiJ_G0026387
 protein coding gene Chr3:30432575-30638911 (-)



Homology
more
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
  • Synonyms
    PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b
  • Links
    NCBI Gene ID: 51555
    neXtProt AC: NX_Q8IYB4
    UniProt: Q8IYB4

  • Chr Location
    3q26.33; chr3:179794958-180037053 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation lacking isoform b exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    9
  • cDNA Data
    10
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027674 Ensembl Gene Model | MGI Sequence Detail 193840 C57BL/6J ±  kb
transcript ENSMUST00000194016 Ensembl | MGI Sequence Detail 4206 Not Applicable  
polypeptide ENSMUSP00000142196 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:323958 Di Bella DJ, et al., Molecular logic of cellular diversification in the mouse cerebral cortex. Nature. 2021 Jul;595(7868):554-559
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory