Vps37b MGI Mouse Gene Detail - MGI:1916724 - vacuolar protein sorting 37B

Symbol

Vps37b
Name

vacuolar protein sorting 37B
Synonyms

2300007F24Rik

Feature Type

protein coding gene
IDs

MGI:1916724
NCBI Gene: 330192
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:124142704-124170323 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.32 cM
Mapping Data

2 experiments

SNPs within 2kb

873 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916724	protein coding gene	Chr5:124142704-124170333 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030086	protein coding gene	Chr5:127781747-127812613 (-)
A/J	MGP_AJ_G0030051	protein coding gene	Chr5:122475149-122503105 (-)
AKR/J	MGP_AKRJ_G0029987	protein coding gene	Chr5:126410917-126442209 (-)
BALB/cJ	MGP_BALBcJ_G0030062	protein coding gene	Chr5:123803859-123831763 (-)
C3H/HeJ	MGP_C3HHeJ_G0029779	protein coding gene	Chr5:127025632-127053331 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030515	protein coding gene	Chr5:132731940-132761041 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027741	protein coding gene	Chr5:117011589-117039620 (-)
CAST/EiJ	MGP_CASTEiJ_G0029188	protein coding gene	Chr5:126141468-126171169 (-)
CBA/J	MGP_CBAJ_G0029749	protein coding gene	Chr5:137944332-137971992 (-)
DBA/2J	MGP_DBA2J_G0029899	protein coding gene	Chr5:122494446-122522874 (-)
FVB/NJ	MGP_FVBNJ_G0029855	protein coding gene	Chr5:121531583-121560861 (-)
LP/J	MGP_LPJ_G0029988	protein coding gene	Chr5:128322270-128351281 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029886	protein coding gene	Chr5:141544974-141572710 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030556	protein coding gene	Chr5:126023081-126051679 (-)
PWK/PhJ	MGP_PWKPhJ_G0028902	protein coding gene	Chr5:121305345-121333669 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028739	protein coding gene	Chr5:123689787-123717750 (-)
WSB/EiJ	MGP_WSBEiJ_G0029263	protein coding gene	Chr5:126709206-126736828 (-)

Human Ortholog

VPS37B, VPS37B subunit of ESCRT-I

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPS37B, VPS37B subunit of ESCRT-I
Links

HGNC:25754

NCBI Gene ID: 79720

neXtProt AC: NX_Q9H9H4

UniProt: Q9H9H4
Chr Location

12q24.31; chr12:122865330-122896127 (-) GRCh38

MGI Vertebrate Homology

Vps37b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VPS37B
Gene Tree

Vps37b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Vps37b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

21
cDNA Data

86
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vps37b

ZFIN vps37bb

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS19670.1

Ensembl

ENSMUSG00000066278 (Evidence)
NCBI Gene

330192

			Length	Strain/Species	Flank
genomic	330192	NCBI Gene Model \| MGI Sequence Detail	27620	C57BL/6J	± kb
transcript	NM_177876	RefSeq \| MGI Sequence Detail	2512	C57BL/6
polypeptide	Q8R0J7	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017336 vacuolar protein sorting-associated protein 37B

(term hierarchy)
InterPro Domains

IPR037202 ESCRT assembly domain

IPR029012 Helix hairpin bin domain superfamily

IPR009851 Modifier of rudimentary, Modr

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All nucleic 89

cDNA 87

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2140864

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vps37b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53291	Chr5:124170277-124170353 (-)	8 bp
Tssr53290	Chr5:124169081-124169085 (-)	1,240 bp
Tssr53289	Chr5:124148853-124148866 (-)	21,463 bp
Tssr53288	Chr5:124148775-124148781 (-)	21,545 bp
Tssr53287	Chr5:124144614-124144632 (-)	25,700 bp
Tssr53286	Chr5:124144534-124144557 (-)	25,777 bp
Tssr53285	Chr5:124144178-124144217 (-)	26,125 bp
Tssr53284	Chr5:124143680-124143711 (-)	26,627 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24