Ttc9 MGI Mouse Gene Detail - MGI:1916730 - tetratricopeptide repeat domain 9

Symbol

Ttc9
Name

tetratricopeptide repeat domain 9
Synonyms

1700029M07Rik

Feature Type

protein coding gene
IDs

MGI:1916730
NCBI Gene: 69480
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:81678023-81714331 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 37.85 cM
Mapping Data

2 experiments

SNPs within 2kb

951 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916730	protein coding gene	Chr12:81678023-81714331 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019906	protein coding gene	Chr12:82108713-82143104 (+)
A/J	MGP_AJ_G0019863	protein coding gene	Chr12:79104056-79138188 (+)
AKR/J	MGP_AKRJ_G0019839	protein coding gene	Chr12:81252678-81286305 (+)
BALB/cJ	MGP_BALBcJ_G0019843	protein coding gene	Chr12:79331006-79364946 (+)
C3H/HeJ	MGP_C3HHeJ_G0019649	protein coding gene	Chr12:81716911-81751561 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020295	protein coding gene	Chr12:84492950-84528017 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017912	protein coding gene	Chr12:76072249-76106200 (+)
CAST/EiJ	MGP_CASTEiJ_G0019198	protein coding gene	Chr12:76604981-76638249 (+)
CBA/J	MGP_CBAJ_G0019620	protein coding gene	Chr12:87772015-87812019 (+)
DBA/2J	MGP_DBA2J_G0019735	protein coding gene	Chr12:78682710-78716303 (+)
FVB/NJ	MGP_FVBNJ_G0019721	protein coding gene	Chr12:77532384-77565884 (+)
LP/J	MGP_LPJ_G0019807	protein coding gene	Chr12:82023227-82059539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019760	protein coding gene	Chr12:90767885-90803043 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020329	protein coding gene	Chr12:80782763-80817600 (+)
PWK/PhJ	MGP_PWKPhJ_G0018963	protein coding gene	Chr12:73089569-73123952 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018757	protein coding gene	Chr12:75300747-75333331 (+)
WSB/EiJ	MGP_WSBEiJ_G0019250	protein coding gene	Chr12:81433624-81467620 (+)

Human Ortholog

TTC9, tetratricopeptide repeat domain 9

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TTC9, tetratricopeptide repeat domain 9
Synonyms

TTC9A
Links

HGNC:20267

NCBI Gene ID: 23508

neXtProt AC: NX_Q92623

UniProt: Q92623
Chr Location

14q24.2; chr14:70641916-70675366 (+) GRCh38

MGI Vertebrate Homology

Ttc9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TTC9
Gene Tree

Ttc9

Diseases

1 with human TTC9 associations

				Human Disease	Mouse Models
				opiate dependence IDs opiate dependence DOID:2559 ICD10CM:F11.2 ICD9CM_2006:304.0 ICD9CM:304.0 ICD9CM:304.00 MESH:D009293 UMLS_CUI:C0524662

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Ttc9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO adult females display increased body, thymus and spleen weights and improved mammary development and sensitivity to estrogen.

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

25
cDNA Data

29
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS26024.1

Ensembl

ENSMUSG00000042734 (Evidence)
NCBI Gene

69480

			Length	Strain/Species	Flank
genomic	69480	NCBI Gene Model \| MGI Sequence Detail	36309	C57BL/6J	± kb
transcript	NM_001033149	RefSeq \| MGI Sequence Detail	4793	C57BL/6
polypeptide	Q3V038	UniProt \| EBI \| MGI Sequence Detail	219	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032787 tetratricopeptide repeat protein 9A

(term hierarchy)
InterPro Domains

IPR050754 Immunophilin FKBP-type domain-containing protein

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 29

cDNA 29

Microarray probesets 5

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MGI:2144821, MGI:2144907

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:241702 Lim LW, et al., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice. Sci Rep. 2016 Nov 21;6:37568

TSS for Ttc9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114197	Chr12:81677820-81677895 (+)	-165 bp
Tssr114198	Chr12:81678002-81678086 (+)	21 bp
Tssr114199	Chr12:81678154-81678168 (+)	138 bp
Tssr114200	Chr12:81710113-81710122 (+)	32,095 bp
Tssr114201	Chr12:81710132-81710152 (+)	32,119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24