Hemk1 MGI Mouse Gene Detail - MGI:1916786 - HemK methyltransferase family member 1

Symbol

Hemk1
Name

HemK methyltransferase family member 1
Synonyms

2310008M14Rik

Feature Type

protein coding gene
IDs

MGI:1916786
NCBI Gene: 69536
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:107204283-107215549 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 58.00 cM
Mapping Data

2 experiments

SNPs within 2kb

421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916786	protein coding gene	Chr9:107204281-107217640 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035250	protein coding gene	Chr9:109183643-109194750 (-)
A/J	MGP_AJ_G0035229	protein coding gene	Chr9:105222675-105233764 (-)
AKR/J	MGP_AKRJ_G0035161	protein coding gene	Chr9:107845404-107857855 (-)
BALB/cJ	MGP_BALBcJ_G0035223	protein coding gene	Chr9:104891563-104903112 (-)
C3H/HeJ	MGP_C3HHeJ_G0034933	protein coding gene	Chr9:108244757-108255825 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035743	protein coding gene	Chr9:112186447-112197763 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032641	protein coding gene	Chr9:102651215-102662442 (-)
CAST/EiJ	MGP_CASTEiJ_G0034244	protein coding gene	Chr9:108177478-108188664 (-)
CBA/J	MGP_CBAJ_G0034901	protein coding gene	Chr9:116160069-116171240 (-)
DBA/2J	MGP_DBA2J_G0035062	protein coding gene	Chr9:104675802-104687258 (-)
FVB/NJ	MGP_FVBNJ_G0035010	protein coding gene	Chr9:103437980-103449322 (-)
LP/J	MGP_LPJ_G0035138	protein coding gene	Chr9:109392004-109404437 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035049	protein coding gene	Chr9:117748454-117761481 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035764	protein coding gene	Chr9:108111402-108125708 (-)
PWK/PhJ	MGP_PWKPhJ_G0033951	protein coding gene	Chr9:104989418-105003096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033786	protein coding gene	Chr9:108178706-108192055 (-)
WSB/EiJ	MGP_WSBEiJ_G0034365	protein coding gene	Chr9:107999839-108012931 (-)

Human Ortholog

HEMK1, HemK methyltransferase family member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HEMK1, HemK methyltransferase family member 1
Synonyms

HEMK, MPRMC, MTQ1
Links

HGNC:24923

NCBI Gene ID: 51409

neXtProt AC: NX_Q9Y5R4

UniProt: Q9Y5R4
Chr Location

3p21.31; chr3:50569152-50596168 (+) GRCh38

MGI Vertebrate Homology

Hemk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HEMK1
Gene Tree

Hemk1

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

23
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hemk1

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All Sequences

60
RefSeq

20
UniProt

3
CCDS

CCDS23488.1

Ensembl

ENSMUSG00000032579 (Evidence)
NCBI Gene

69536

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032579	Ensembl Gene Model \| MGI Sequence Detail	11267	C57BL/6J	± kb
transcript	ENSMUST00000035196	Ensembl \| MGI Sequence Detail	2192	Not Applicable
polypeptide	ENSMUSP00000035196	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032294 MTRF1L release factor glutamine methyltransferase

(term hierarchy)
EC

2.1.1.297
InterPro Domains

IPR002052 DNA methylase, N-6 adenine-specific, conserved site

IPR004556 Methyltransferase HemK-like

IPR007848 Methyltransferase small domain

IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific

IPR050320 Protein N5-glutamine methyltransferase

IPR040758 Release factor glutamine methyltransferase, N-terminal domain

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 23

cDNA 23

Microarray probesets 4

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MGI:2143281

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Hemk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91389	Chr9:107215504-107215550 (-)	22 bp
Tssr3008	Chr9:107215497-107215501 (-)	50 bp
Tssr91388	Chr9:107215194-107215198 (-)	353 bp
Tssr91387	Chr9:107211804-107211817 (-)	3,738 bp
Tssr91386	Chr9:107211769-107211782 (-)	3,773 bp
Tssr91385	Chr9:107211514-107211521 (-)	4,031 bp
Tssr91384	Chr9:107211012-107211027 (-)	4,529 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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