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Lyg1 Gene Detail
Summary
  • Symbol
    Lyg1
  • Name
    lysozyme G-like 1
  • Synonyms
    2300002O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916791
    NCBI Gene: 69541
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37985819-37996840 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 16.29 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    445 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916791
 protein coding gene Chr1:37985817-37996840 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015946
 protein coding gene Chr1:36597945-36610174 (-)
A/J MGP_AJ_G0015930
 protein coding gene Chr1:35592685-35604478 (-)
AKR/J MGP_AKRJ_G0015885
 protein coding gene Chr1:36086425-36097493 (-)
BALB/cJ MGP_BALBcJ_G0015884
 protein coding gene Chr1:35243535-35254815 (-)
C3H/HeJ MGP_C3HHeJ_G0015717
 protein coding gene Chr1:36307712-36318740 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016337
 protein coding gene Chr1:38186322-38197337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014059
 protein coding gene Chr1:32581174-32592244 (-)
CAST/EiJ MGP_CASTEiJ_G0015298
 protein coding gene Chr1:36166923-36178989 (-)
CBA/J MGP_CBAJ_G0015689
 protein coding gene Chr1:39238748-39249792 (-)
DBA/2J MGP_DBA2J_G0015790
 protein coding gene Chr1:34895692-34907108 (-)
FVB/NJ MGP_FVBNJ_G0015792
 protein coding gene Chr1:34427724-34438615 (-)
LP/J MGP_LPJ_G0015860
 protein coding gene Chr1:36953133-36964153 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015812
 protein coding gene Chr1:41390148-41402049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016384
 protein coding gene Chr1:36155431-36166434 (-)
PWK/PhJ MGP_PWKPhJ_G0015081
 protein coding gene Chr1:34678661-34689906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014863
 protein coding gene Chr1:36104634-36115588 (-)
WSB/EiJ MGP_WSBEiJ_G0015360
 protein coding gene Chr1:36114733-36126981 (-)



Homology
more
  • Human Ortholog
    LYG1, lysozyme g1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYG1, lysozyme g1
  • Synonyms
    LYGA1, SALW1939
  • Links
    NCBI Gene ID: 129530
    neXtProt AC: NX_Q8N1E2
    UniProt: Q8N1E2

  • Chr Location
    2q11.2; chr2:99284238-99304775 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibit accelerated tumor growth, reduced numbers of CD4+ and CD8+ T cells and decreased production of interferon gamma by T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69541 NCBI Gene Model | MGI Sequence Detail 11022 C57BL/6J ±  kb
transcript NM_027111 RefSeq | MGI Sequence Detail 798 C57BL/6  
polypeptide Q9D7Q0 UniProt | EBI | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:311877 Liu H, et al., LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells. Front Immunol. 2021;12:647894
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory