Rhou MGI Mouse Gene Detail - MGI:1916831 - ras homolog family member U

Symbol

Rhou
Name

ras homolog family member U
Synonyms

2310026M05Rik, Arhu, CDC42L1, mG28K, WRCH-1, WRCH1

Feature Type

protein coding gene
IDs

MGI:1916831
NCBI Gene: 69581
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:124380668-124390623 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.10 cM
Mapping Data

2 experiments

SNPs within 2kb

243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916831	protein coding gene	Chr8:124380609-124390623 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034260	protein coding gene	Chr8:127265143-127275083 (+)
A/J	MGP_AJ_G0034240	protein coding gene	Chr8:122031866-122042070 (+)
AKR/J	MGP_AKRJ_G0034167	protein coding gene	Chr8:125537095-125547217 (+)
BALB/cJ	MGP_BALBcJ_G0034233	protein coding gene	Chr8:122211340-122221987 (+)
C3H/HeJ	MGP_C3HHeJ_G0033944	protein coding gene	Chr8:126172278-126183327 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034753	protein coding gene	Chr8:131549203-131559183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031695	protein coding gene	Chr8:114812171-114822076 (+)
CAST/EiJ	MGP_CASTEiJ_G0033272	protein coding gene	Chr8:126276148-126286045 (+)
CBA/J	MGP_CBAJ_G0033917	protein coding gene	Chr8:136349484-136359445 (+)
DBA/2J	MGP_DBA2J_G0034073	protein coding gene	Chr8:121185161-121195145 (+)
FVB/NJ	MGP_FVBNJ_G0034017	protein coding gene	Chr8:120341558-120351980 (+)
LP/J	MGP_LPJ_G0034163	protein coding gene	Chr8:127437163-127447098 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034064	protein coding gene	Chr8:138496244-138506253 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034772	protein coding gene	Chr8:125763903-125773856 (+)
PWK/PhJ	MGP_PWKPhJ_G0032973	protein coding gene	Chr8:120925154-120935634 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032813	protein coding gene	Chr8:124405748-124421207 (+)
WSB/EiJ	MGP_WSBEiJ_G0033388	protein coding gene	Chr8:126492945-126502885 (+)

Human Ortholog

RHOU, ras homolog family member U

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOU, ras homolog family member U
Synonyms

ARHU, CDC42L1, G28K, hG28K, WRCH1
Links

HGNC:17794

NCBI Gene ID: 58480

neXtProt AC: NX_Q7L0Q8

UniProt: Q7L0Q8
Chr Location

1q42.13; chr1:228644647-228746669 (+) GRCh38

MGI Vertebrate Homology

Rhou stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: RHOU
Gene Tree

Rhou

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

22
cDNA Data

70
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOU

Xenbase rhou

ZFIN rhoua, rhoub

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All Sequences

38
RefSeq

2
UniProt

4
CCDS

CCDS22762.1

Ensembl

ENSMUSG00000039960 (Evidence)
NCBI Gene

69581

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039960	Ensembl Gene Model \| MGI Sequence Detail	9956	C57BL/6J	± kb
transcript	ENSMUST00000045487	Ensembl \| MGI Sequence Detail	3371	Not Applicable
polypeptide	ENSMUSP00000038915	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013987 Rho-related GTP-binding protein RhoU

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 73

cDNA 70

Primer pair 2

Other 1

Microarray probesets 5

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MGI:2142472

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rhou:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79981	Chr8:124380530-124380544 (+)	-131 bp
Tssr79982	Chr8:124380546-124380557 (+)	-116 bp
Tssr79983	Chr8:124380562-124380573 (+)	-100 bp
Tssr79984	Chr8:124380580-124380616 (+)	-70 bp
Tssr79985	Chr8:124380642-124380647 (+)	-23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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