Ap5s1 MGI Mouse Gene Detail - MGI:1916846 - adaptor-related protein 5 complex, sigma 1 subunit

Symbol

Ap5s1
Name

adaptor-related protein 5 complex, sigma 1 subunit
Synonyms

0610038L13Rik, 2310035K24Rik

Feature Type

protein coding gene
IDs

MGI:1916846
NCBI Gene: 69596
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:131052280-131055434 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.29 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916846	protein coding gene	Chr2:131048998-131055434 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026527	protein coding gene	Chr2:134721622-134728928 (+)
A/J	MGP_AJ_G0026491	protein coding gene	Chr2:129253512-129260269 (+)
AKR/J	MGP_AKRJ_G0026466	protein coding gene	Chr2:132986830-132993000 (+)
BALB/cJ	MGP_BALBcJ_G0026503	protein coding gene	Chr2:129640143-129647076 (+)
C3H/HeJ	MGP_C3HHeJ_G0026246	protein coding gene	Chr2:133421904-133430446 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026948	protein coding gene	Chr2:138856332-138865151 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024325	protein coding gene	Chr2:123998768-124004913 (+)
CAST/EiJ	MGP_CASTEiJ_G0025707	protein coding gene	Chr2:133703895-133711601 (+)
CBA/J	MGP_CBAJ_G0026226	protein coding gene	Chr2:144030828-144039285 (+)
DBA/2J	MGP_DBA2J_G0026360	protein coding gene	Chr2:128644049-128650284 (+)
FVB/NJ	MGP_FVBNJ_G0026324	protein coding gene	Chr2:127273820-127280241 (+)
LP/J	MGP_LPJ_G0026465	protein coding gene	Chr2:134949176-134957072 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026344	protein coding gene	Chr2:147851264-147858487 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027003	protein coding gene	Chr2:132944136-132958261 (+)
PWK/PhJ	MGP_PWKPhJ_G0025443	protein coding gene	Chr2:128214322-128220641 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025245	protein coding gene	Chr2:132096099-132102266 (+)
WSB/EiJ	MGP_WSBEiJ_G0025781	protein coding gene	Chr2:133866247-133872456 (+)

Human Ortholog

AP5S1, adaptor related protein complex 5 subunit sigma 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AP5S1, adaptor related protein complex 5 subunit sigma 1
Synonyms

C20orf29
Links

HGNC:15875

NCBI Gene ID: 55317

neXtProt AC: NX_Q9NUS5

UniProt: Q9NUS5
Chr Location

20p13; chr20:3820524-3828838 (+) GRCh38

MGI Vertebrate Homology

Ap5s1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AP5S1
Gene Tree

Ap5s1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ap5s1
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

24
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ap5s1

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All Sequences

58
RefSeq

9
UniProt

6
CCDS

CCDS16759.1, CCDS71147.1, CCDS71148.1, CCDS89557.1

Ensembl

ENSMUSG00000068264 (Evidence)
NCBI Gene

69596

			Length	Strain/Species	Flank
genomic	69596	NCBI Gene Model \| MGI Sequence Detail	3155	C57BL/6J	± kb
transcript	NM_001291031	RefSeq \| MGI Sequence Detail	1617	C57BL/6
polypeptide	Q9D742	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032320 AP-5 complex subunit sigma-1

(term hierarchy)
InterPro Domains

IPR029392 AP-5 complex subunit sigma-1

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All nucleic 35

cDNA 35

Microarray probesets 4

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MGI:1917594, MGI:2139290

Summaries

All 37

Gene Ontology 6

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:320005 Hirst J, et al., The fifth adaptor protein complex. PLoS Biol. 2011 Oct;9(10):e1001170

TSS for Ap5s1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20255	Chr2:131052283-131052396 (+)	60 bp
Tssr20256	Chr2:131052421-131052472 (+)	167 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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