Pofut2 MGI Mouse Gene Detail - MGI:1916863 - protein O-fucosyltransferase 2

Symbol

Pofut2
Name

protein O-fucosyltransferase 2
Synonyms

2310011G23Rik, FUT13, MGC:6943

Feature Type

protein coding gene
IDs

MGI:1916863
NCBI Gene: 80294
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:77095052-77105409 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

388 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916863	protein coding gene	Chr10:77095052-77105420 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017395	protein coding gene	Chr10:77555339-77565625 (+)
A/J	MGP_AJ_G0017372	protein coding gene	Chr10:74874551-74884837 (+)
AKR/J	MGP_AKRJ_G0017333	protein coding gene	Chr10:76884258-76894544 (+)
BALB/cJ	MGP_BALBcJ_G0017332	protein coding gene	Chr10:75066059-75076345 (+)
C3H/HeJ	MGP_C3HHeJ_G0017156	protein coding gene	Chr10:76961658-76971944 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017790	protein coding gene	Chr10:80285794-80296080 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015480	protein coding gene	Chr10:71302464-71312876 (+)
CAST/EiJ	MGP_CASTEiJ_G0016726	protein coding gene	Chr10:77305472-77315922 (+)
CBA/J	MGP_CBAJ_G0017128	protein coding gene	Chr10:83416708-83426994 (+)
DBA/2J	MGP_DBA2J_G0017233	protein coding gene	Chr10:74159981-74170267 (+)
FVB/NJ	MGP_FVBNJ_G0017225	protein coding gene	Chr10:73329150-73339436 (+)
LP/J	MGP_LPJ_G0017306	protein coding gene	Chr10:78028512-78038798 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017254	protein coding gene	Chr10:85446585-85456871 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017829	protein coding gene	Chr10:76954461-76964747 (+)
PWK/PhJ	MGP_PWKPhJ_G0016510	protein coding gene	Chr10:74023981-74034412 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016293	protein coding gene	Chr10:76218662-76228999 (+)
WSB/EiJ	MGP_WSBEiJ_G0016789	protein coding gene	Chr10:76930654-76941020 (+)

Human Ortholog

POFUT2, protein O-fucosyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POFUT2, protein O-fucosyltransferase 2
Synonyms

C21orf80, FUT13
Links

HGNC:14683

NCBI Gene ID: 23275

neXtProt AC: NX_Q9Y2G5

UniProt: Q9Y2G5
Chr Location

21q22.3; chr21:45263928-45287898 (-) GRCh38

MGI Vertebrate Homology

Pofut2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POFUT2
Gene Tree

Pofut2

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References

2 with disease annotations

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Phenotype Summary

20 phenotypes from 4 alleles in 5 genetic backgrounds
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Targeted

6
Genomic Mutations

4 involving Pofut2
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in lethality before weaning.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

988
Tissues

163
cDNA Data

92
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pofut2

ZFIN pofut2

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All Sequences

70
RefSeq

4
UniProt

7
CCDS

CCDS23954.1

Ensembl

ENSMUSG00000020260 (Evidence)
NCBI Gene

80294

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020260	Ensembl Gene Model \| MGI Sequence Detail	10358	C57BL/6J	± kb
transcript	ENSMUST00000020493	Ensembl \| MGI Sequence Detail	2290	Not Applicable
polypeptide	ENSMUSP00000020493	Ensembl \| MGI Sequence Detail	429	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012959 GDP-fucose protein O-fucosyltransferase 2

(term hierarchy)
EC

2.4.1.221
InterPro Domains

IPR019378 GDP-fucose protein O-fucosyltransferase

IPR045130 GDP-fucose protein O-fucosyltransferase 2-like
GlyGen

Q8VHI3 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 101

cDNA 94

Primer pair 5

Other 2

Microarray probesets 4

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MGI:1933140, MGI:2143552

Summaries

All 77

Developmental Gene Expression 10

Diseases 2

Gene Ontology 9

Phenotypes 43
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Pofut2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94220	Chr10:77095114-77095182 (+)	96 bp
Tssr94221	Chr10:77095188-77095198 (+)	141 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24