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Arhgef12 Gene Detail
Summary
  • Symbol
    Arhgef12
  • Name
    Rho guanine nucleotide exchange factor 12
  • Synonyms
    2310014B11Rik, LARG, mKIAA0382
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916882
    NCBI Gene: 69632
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:42875138-43017069 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.14 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2736 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916882
 protein coding gene Chr9:42875138-43018534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034680
 protein coding gene Chr9:41334878-41487283 (-)
A/J MGP_AJ_G0034660
 protein coding gene Chr9:40232762-40378357 (-)
AKR/J MGP_AKRJ_G0034586
 protein coding gene Chr9:41015172-41159994 (-)
BALB/cJ MGP_BALBcJ_G0034651
 protein coding gene Chr9:39961330-40104623 (-)
C3H/HeJ MGP_C3HHeJ_G0034362
 protein coding gene Chr9:41509550-41654062 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035174
 protein coding gene Chr9:42599168-42746697 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032087
 protein coding gene Chr9:39845970-39988045 (-)
CAST/EiJ MGP_CASTEiJ_G0033685
 protein coding gene Chr9:41311670-41459571 (-)
CBA/J MGP_CBAJ_G0034335
 protein coding gene Chr9:44105419-44262468 (-)
DBA/2J MGP_DBA2J_G0034494
 protein coding gene Chr9:40149552-40290449 (-)
FVB/NJ MGP_FVBNJ_G0034434
 protein coding gene Chr9:39384605-39525703 (-)
LP/J MGP_LPJ_G0034575
 protein coding gene Chr9:41621878-41771862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034478
 protein coding gene Chr9:46059521-46207479 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035193
 protein coding gene Chr9:40922967-41071044 (-)
PWK/PhJ MGP_PWKPhJ_G0033390
 protein coding gene Chr9:39988898-40135996 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033226
 protein coding gene Chr9:41212792-41358737 (-)
WSB/EiJ MGP_WSBEiJ_G0033798
 protein coding gene Chr9:40976414-41120689 (-)



Homology
more
  • Human Ortholog
    ARHGEF12, Rho guanine nucleotide exchange factor 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF12, Rho guanine nucleotide exchange factor 12
  • Synonyms
    LARG, PRO2792
  • Links
    NCBI Gene ID: 23365
    neXtProt AC: NX_Q9NZN5
    UniProt: Q9NZN5

  • Chr Location
    11q23.3; chr11:120336413-120489937 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    90
  • cDNA Data
    18
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69632 NCBI Gene Model | MGI Sequence Detail 141932 C57BL/6J ±  kb
    transcript NM_027144 RefSeq | MGI Sequence Detail 10483 Not Specified  
    polypeptide Q8R4H2 UniProt | EBI | MGI Sequence Detail 1543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143206
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory