Dapk1 MGI Mouse Gene Detail - MGI:1916885 - death associated protein kinase 1

Symbol

Dapk1
Name

death associated protein kinase 1
Synonyms

2310039H24Rik, 2810425C21Rik, D13Ucla1, DAP-Kinase

Feature Type

protein coding gene
IDs

MGI:1916885
NCBI Gene: 69635
Alliance

gene page
Transcription Start Sites

24 TSS

Sequence Map

Chr13:60749761-60911005 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 32.53 cM
Mapping Data

5 experiments

SNPs within 2kb

5630 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916885	protein coding gene	Chr13:60749506-60911005 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020648	protein coding gene	Chr13:60375131-60544667 (+)
A/J	MGP_AJ_G0020603	protein coding gene	Chr13:58110935-58272345 (+)
AKR/J	MGP_AKRJ_G0020579	protein coding gene	Chr13:59837009-60004130 (+)
BALB/cJ	MGP_BALBcJ_G0020599	protein coding gene	Chr13:58364649-58529460 (+)
C3H/HeJ	MGP_C3HHeJ_G0020396	protein coding gene	Chr13:59633547-59799706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021033	protein coding gene	Chr13:62163610-62348288 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018615	protein coding gene	Chr13:55974897-56137555 (+)
CAST/EiJ	MGP_CASTEiJ_G0019912	protein coding gene	Chr13:59858067-60026152 (+)
CBA/J	MGP_CBAJ_G0020356	protein coding gene	Chr13:64513723-64687585 (+)
DBA/2J	MGP_DBA2J_G0020480	protein coding gene	Chr13:57637403-57798678 (+)
FVB/NJ	MGP_FVBNJ_G0020458	protein coding gene	Chr13:57138391-57299165 (+)
LP/J	MGP_LPJ_G0020556	protein coding gene	Chr13:60628662-60794702 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020488	protein coding gene	Chr13:63782438-63952997 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021076	protein coding gene	Chr13:59435786-59604640 (+)
PWK/PhJ	MGP_PWKPhJ_G0019667	protein coding gene	Chr13:57687970-57853090 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019494	protein coding gene	Chr13:58363111-58542429 (+)
WSB/EiJ	MGP_WSBEiJ_G0019974	protein coding gene	Chr13:59897065-60067237 (+)

Human Ortholog

DAPK1, death associated protein kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAPK1, death associated protein kinase 1
Synonyms

DAPK, ROCO3
Links

HGNC:2674

NCBI Gene ID: 1612

neXtProt AC: NX_P53355

UniProt: P53355
Chr Location

9q21.33; chr9:87497228-87708634 (+) GRCh38

MGI Vertebrate Homology

Dapk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAPK1
Gene Tree

Dapk1

Diseases

2 with human DAPK1 associations

				Human Disease	Mouse Models
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				uterine fibroid IDs uterine fibroid DOID:13223 EFO:0000731 ICD10CM:D25 ICD9CM_2006:218 ICD9CM:218 ICD9CM:218.9 MESH:D007889 NCI:C3434 OMIM:150699 UMLS_CUI:C0042133

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

24
Targeted

9
Genomic Mutations

1 involving Dapk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

126 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury.

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All GO Annotations

82
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

83
cDNA Data

108
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dapk1

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All Sequences

75
RefSeq

18
UniProt

3
CCDS

CCDS26581.1, CCDS88466.1

Ensembl

ENSMUSG00000021559 (Evidence)
NCBI Gene

69635

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021559	Ensembl Gene Model \| MGI Sequence Detail	161245	C57BL/6J	± kb
transcript	ENSMUST00000226059	Ensembl \| MGI Sequence Detail	5009	Not Applicable
polypeptide	ENSMUSP00000153607	Ensembl \| MGI Sequence Detail	1442	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006276 death-associated protein kinase 1

(term hierarchy)
PDB

8ODZ
EC

2.7.11.1
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR020676 Death-associated protein kinase 1, catalytic domain

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR020859 Roc domain

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q80YE7 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 113

cDNA 109

Primer pair 2

Other 2

Microarray probesets 6

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MGD-MRK-3671, MGI:1923806, MGI:2145272, MGI:89882

Summaries

All 100

Developmental Gene Expression 12

Gene Ontology 15

Phenotypes 39
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dapk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120113	Chr13:60749509-60749518 (+)	-247 bp
Tssr120114	Chr13:60749557-60749568 (+)	-198 bp
Tssr120115	Chr13:60749588-60749602 (+)	-166 bp
Tssr120116	Chr13:60749735-60749853 (+)	33 bp
Tssr120117	Chr13:60749996-60750045 (+)	260 bp
Tssr120118	Chr13:60751403-60751414 (+)	1,648 bp
Tssr4097	Chr13:60754777-60754782 (+)	5,019 bp
Tssr120119	Chr13:60756278-60756281 (+)	6,519 bp
Tssr120120	Chr13:60758369-60758373 (+)	8,610 bp
Tssr120121	Chr13:60761623-60761629 (+)	11,865 bp
Tssr120122	Chr13:60784355-60784369 (+)	34,601 bp
Tssr120125	Chr13:60794723-60794739 (+)	44,970 bp
Tssr120126	Chr13:60795320-60795324 (+)	45,561 bp
Tssr120127	Chr13:60795570-60795585 (+)	45,817 bp
Tssr120128	Chr13:60820805-60820818 (+)	71,051 bp
Tssr120129	Chr13:60877194-60877199 (+)	127,436 bp
Tssr120130	Chr13:60881639-60881656 (+)	131,887 bp
Tssr120131	Chr13:60885965-60885976 (+)	136,210 bp
Tssr120132	Chr13:60887746-60887760 (+)	137,992 bp
Tssr120133	Chr13:60899626-60899642 (+)	149,873 bp
Tssr120134	Chr13:60909741-60909756 (+)	159,988 bp
Tssr120135	Chr13:60910281-60910296 (+)	160,528 bp
Tssr120136	Chr13:60910326-60910341 (+)	160,573 bp
Tssr120137	Chr13:60910361-60910401 (+)	160,620 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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