Fam83g MGI Mouse Gene Detail - MGI:1916890 - family with sequence similarity 83, member G

Symbol

Fam83g
Name

family with sequence similarity 83, member G
Synonyms

2310040C09Rik, wly

Feature Type

protein coding gene
IDs

MGI:1916890
NCBI Gene: 69640
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:61574917-61600777 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM
Mapping Data

3 experiments

SNPs within 2kb

573 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916890	protein coding gene	Chr11:61574908-61600777 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018445	protein coding gene	Chr11:61656631-61682461 (+)
A/J	MGP_AJ_G0018414	protein coding gene	Chr11:59383694-59409441 (+)
AKR/J	MGP_AKRJ_G0018384	protein coding gene	Chr11:61224925-61250751 (+)
BALB/cJ	MGP_BALBcJ_G0018385	protein coding gene	Chr11:59686577-59712417 (+)
C3H/HeJ	MGP_C3HHeJ_G0018198	protein coding gene	Chr11:61211920-61237796 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018837	protein coding gene	Chr11:63619442-63645319 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016483	protein coding gene	Chr11:56499724-56525596 (+)
CAST/EiJ	MGP_CASTEiJ_G0017755	protein coding gene	Chr11:61316855-61343053 (+)
CBA/J	MGP_CBAJ_G0018172	protein coding gene	Chr11:66378544-66404365 (+)
DBA/2J	MGP_DBA2J_G0018281	protein coding gene	Chr11:58952706-58978520 (+)
FVB/NJ	MGP_FVBNJ_G0018272	protein coding gene	Chr11:58637102-58664017 (+)
LP/J	MGP_LPJ_G0018354	protein coding gene	Chr11:62229248-62255078 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018296	protein coding gene	Chr11:67370463-67396260 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018878	protein coding gene	Chr11:61363098-61388928 (+)
PWK/PhJ	MGP_PWKPhJ_G0017528	protein coding gene	Chr11:59558594-59582918 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017318	protein coding gene	Chr11:61189691-61213835 (+)
WSB/EiJ	MGP_WSBEiJ_G0017807	protein coding gene	Chr11:60970879-60994489 (+)

Human Ortholog

FAM83G, family with sequence similarity 83 member G

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM83G, family with sequence similarity 83 member G
Synonyms

PAWS1
Links

HGNC:32554

NCBI Gene ID: 644815

neXtProt AC: NX_A6ND36

UniProt: A6ND36
Chr Location

17p11.2; chr17:18968789-19006116 (-) GRCh38

MGI Vertebrate Homology

Fam83g stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FAM83G
Gene Tree

Fam83g

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

2
Spontaneous

1
Targeted

5
Genomic Mutations

1 involving Fam83g
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations at this locus result in curly hair.

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam83g

ZFIN fam83gb

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All Sequences

44
RefSeq

6
UniProt

3
CCDS

CCDS36175.1

Ensembl

ENSMUSG00000042377 (Evidence)
NCBI Gene

69640

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042377	Ensembl Gene Model \| MGI Sequence Detail	25861	C57BL/6J	± kb
transcript	ENSMUST00000093019	Ensembl \| MGI Sequence Detail	4778	Not Applicable
polypeptide	ENSMUSP00000090697	Ensembl \| MGI Sequence Detail	812	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029485 protein FAM83G

(term hierarchy)
InterPro Domains

IPR012461 FAM83, N-terminal

IPR050944 Family with sequence similarity 83 (FAM83)

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All nucleic 8

cDNA 8

Microarray probesets 4

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MGI:2144214, MGI:2668516

Summaries

All 34

Gene Ontology 3

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam83g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101980	Chr11:61574904-61574922 (+)	-4 bp
Tssr101981	Chr11:61575250-61575280 (+)	348 bp
Tssr101982	Chr11:61575282-61575297 (+)	373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24