About   Help   FAQ
Emc10 Gene Detail
Summary
  • Symbol
    Emc10
  • Name
    ER membrane protein complex subunit 10
  • Synonyms
    2310044H10Rik, 5430410O10Rik, Mirta22
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916933
    NCBI Gene: 69683
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44139361-44145953 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916933
 protein coding gene Chr7:44139361-44145953 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032164
 protein coding gene Chr7:44663515-44670107 (-)
A/J MGP_AJ_G0032143
 protein coding gene Chr7:43846264-43852856 (-)
AKR/J MGP_AKRJ_G0032079
 protein coding gene Chr7:45048779-45055371 (-)
BALB/cJ MGP_BALBcJ_G0032155
 protein coding gene Chr7:43842350-43848942 (-)
C3H/HeJ MGP_C3HHeJ_G0031871
 protein coding gene Chr7:45539724-45546316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032647
 protein coding gene Chr7:46921557-46928149 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029661
 protein coding gene Chr7:46431013-46437697 (-)
CAST/EiJ MGP_CASTEiJ_G0031199
 protein coding gene Chr7:36916695-36923302 (-)
CBA/J MGP_CBAJ_G0031835
 protein coding gene Chr7:48448986-48455578 (-)
DBA/2J MGP_DBA2J_G0031993
 protein coding gene Chr7:43519814-43526341 (-)
FVB/NJ MGP_FVBNJ_G0031944
 protein coding gene Chr7:43255880-43265951 (-)
LP/J MGP_LPJ_G0032071
 protein coding gene Chr7:45346274-45352866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031981
 protein coding gene Chr7:47194836-47201428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032663
 protein coding gene Chr7:44265243-44271835 (-)
PWK/PhJ MGP_PWKPhJ_G0030922
 protein coding gene Chr7:36868240-36874775 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030759
 protein coding gene Chr7:32273320-32279934 (-)
WSB/EiJ MGP_WSBEiJ_G0031316
 protein coding gene Chr7:44727645-44734237 (-)



Homology
more
  • Human Ortholog
    EMC10, ER membrane protein complex subunit 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EMC10, ER membrane protein complex subunit 10
  • Synonyms
    C19orf63, HSM1, HSS1, NEDDFAS
  • Links
    NCBI Gene ID: 284361
    neXtProt AC: NX_Q5UCC4
    UniProt: Q5UCC4

  • Chr Location
    19q13.33; chr19:50476400-50490871 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele show improved glucose tolerance and reduced fertility in males, and an increased anxiety-related response in females. Homozygotes for a knock-out allele show female subfertility and male sterility associated with abnormal sperm morphology, oligozoospermia, asthenozoospermia, impaired capacitation and acrosome reaction, sperm incapacity to fertilize intact or ZP-free oocytes, and ion imbalance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    33
  • cDNA Data
    173
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69683 NCBI Gene Model | MGI Sequence Detail 6593 C57BL/6J ±  kb
    transcript NM_001355107 RefSeq | MGI Sequence Detail 1942 C57BL/6  
    polypeptide Q3TAS6 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031292 ER membrane protein complex subunit 10
      (term hierarchy)
    • InterPro Domains
      IPR051754 Chromatin and ER Membrane Complex Protein
    • GlyGen
      Q3TAS6 1 site, 7 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 174
      Genomic 1
      cDNA 173

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918582
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory