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Aarsd1 Gene Detail
Summary
  • Symbol
    Aarsd1
  • Name
    alanyl-tRNA synthetase domain containing 1
  • Synonyms
    2310044P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916934
    NCBI Gene: 69684
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101297665-101308441 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.95 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916934
 protein coding gene Chr11:101297489-101308441 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019199
 protein coding gene Chr11:104264813-104275394 (-)
A/J MGP_AJ_G0019167
 protein coding gene Chr11:99883440-99893891 (-)
AKR/J MGP_AKRJ_G0019136
 protein coding gene Chr11:102991332-103001725 (-)
BALB/cJ MGP_BALBcJ_G0019141
 protein coding gene Chr11:100377845-100389743 (-)
C3H/HeJ MGP_C3HHeJ_G0018950
 protein coding gene Chr11:103160025-103171214 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019590
 protein coding gene Chr11:107540716-107553134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017216
 protein coding gene Chr11:97285935-97297442 (-)
CAST/EiJ MGP_CASTEiJ_G0018504
 protein coding gene Chr11:104145715-104158393 (-)
CBA/J MGP_CBAJ_G0018919
 protein coding gene Chr11:111973467-111986684 (-)
DBA/2J MGP_DBA2J_G0019031
 protein coding gene Chr11:99405216-99417453 (-)
FVB/NJ MGP_FVBNJ_G0019021
 protein coding gene Chr11:98952962-98963529 (-)
LP/J MGP_LPJ_G0019100
 protein coding gene Chr11:104811996-104822528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019052
 protein coding gene Chr11:111531130-111543165 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019628
 protein coding gene Chr11:103314195-103330657 (-)
PWK/PhJ MGP_PWKPhJ_G0018267
 protein coding gene Chr11:100467214-100483901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018059
 protein coding gene Chr11:103041019-103055657 (-)
WSB/EiJ MGP_WSBEiJ_G0018553
 protein coding gene Chr11:103316264-103328509 (-)



Homology
more
  • Human Ortholog
    AARSD1, alanyl-tRNA synthetase domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AARSD1, alanyl-tRNA synthetase domain containing 1
  • Synonyms
    AlaXp
  • Links
    NCBI Gene ID: 80755
    neXtProt AC: NX_Q9BTE6
    UniProt: Q9BTE6

  • Chr Location
    17q21.31; chr17:42950526-42964498 (-)  GRCh38
  • Human Ortholog
    PTGES3L-AARSD1, PTGES3L-AARSD1 readthrough
  • Links
    NCBI Gene ID: 100885850
    neXtProt AC: NX_Q9BTE6

  • Chr Location
    17q21.31; chr17:42950526-42980528 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    1
  • cDNA Data
    93
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075528 Ensembl Gene Model | MGI Sequence Detail 10777 C57BL/6J ±  kb
transcript ENSMUST00000070395 Ensembl | MGI Sequence Detail 1516 Not Applicable  
polypeptide ENSMUSP00000067912 Ensembl | MGI Sequence Detail 412 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR051335 Alanyl-tRNA Editing Enzymes
    IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
    IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
    IPR012947 Threonyl/alanyl tRNA synthetase, SAD
    IPR009000 Translation protein, beta-barrel domain superfamily
  • GlyGen
    Q3THG9 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 93
    cDNA 93

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144034
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:236196 Echeverria PC, et al., A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation. Mol Cell Biol. 2016 Apr;36(8):1310-21
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory