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Pin4 Gene Detail
Summary
  • Symbol
    Pin4
  • Name
    peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)
  • Synonyms
    2410002I22Rik, EPVH, Par14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916963
    NCBI Gene: 69713
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101163075-101171276 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 45.14 cM, cytoband B2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916963
 protein coding gene ChrX:101163053-101171276 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035969
 protein coding gene ChrX:98694858-98706537 (+)
A/J MGP_AJ_G0035954
 protein coding gene ChrX:98653824-98662081 (+)
AKR/J MGP_AKRJ_G0035870
 protein coding gene ChrX:101504847-101514329 (+)
BALB/cJ MGP_BALBcJ_G0035939
 protein coding gene ChrX:97395677-97403899 (+)
C3H/HeJ MGP_C3HHeJ_G0035647
 protein coding gene ChrX:99074935-99083157 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036467
 protein coding gene ChrX:101597724-101619328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033296
 protein coding gene ChrX:96369212-96377012 (+)
CAST/EiJ MGP_CASTEiJ_G0034933
 protein coding gene ChrX:83381308-83390390 (+)
CBA/J MGP_CBAJ_G0035621
 protein coding gene ChrX:104768868-104777090 (+)
DBA/2J MGP_DBA2J_G0035775
 protein coding gene ChrX:97876543-97884765 (+)
FVB/NJ MGP_FVBNJ_G0035714
 protein coding gene ChrX:97237620-97245842 (+)
LP/J MGP_LPJ_G0035866
 protein coding gene ChrX:99615659-99625840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035748
 protein coding gene ChrX:109296605-109305169 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036493
 protein coding gene ChrX:98344874-98353092 (+)
PWK/PhJ MGP_PWKPhJ_G0034632
 protein coding gene ChrX:80963114-80971383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034460
 protein coding gene ChrX:84297628-84305778 (+)
WSB/EiJ MGP_WSBEiJ_G0035072
 protein coding gene ChrX:97055497-97063718 (+)



Homology
more
  • Human Ortholog
    PIN4, peptidylprolyl cis/trans isomerase, NIMA-interacting 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIN4, peptidylprolyl cis/trans isomerase, NIMA-interacting 4
  • Synonyms
    EPVH, hEPVH, hPar14, hPar17, PAR14, PAR17
  • Links
    NCBI Gene ID: 5303
    neXtProt AC: NX_Q9Y237
    UniProt: Q9Y237

  • Chr Location
    Xq13.1; chrX:72181353-72302926 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69713 NCBI Gene Model | MGI Sequence Detail 8202 C57BL/6J ±  kb
transcript NM_001365090 RefSeq | MGI Sequence Detail 634 C57BL/6  
polypeptide Q9CWW6 UniProt | EBI | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012736 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
    IPR043323 Peptidyl-prolyl cis-trans isomerase PIN4
    IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
  • GlyGen
    Q9CWW6 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201792 Zhang J, et al., Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. J Biol Chem. 2013 Jul 12;288(28):20692-701
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory