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Trip13 Gene Detail
Summary
  • Symbol
    Trip13
  • Name
    thyroid hormone receptor interactor 13
  • Synonyms
    2410002G23Rik, D13Ertd328e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916966
    NCBI Gene: 69716
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74060577-74085855 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916966
 protein coding gene Chr13:74059466-74085903 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020753
 protein coding gene Chr13:74397991-74426940 (-)
A/J MGP_AJ_G0020709
 protein coding gene Chr13:71736028-71763505 (-)
AKR/J MGP_AKRJ_G0020683
 protein coding gene Chr13:73988090-74013735 (-)
BALB/cJ MGP_BALBcJ_G0020706
 protein coding gene Chr13:72229772-72256403 (-)
C3H/HeJ MGP_C3HHeJ_G0020500
 protein coding gene Chr13:73670690-73697900 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021143
 protein coding gene Chr13:76858372-76889916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018710
 protein coding gene Chr13:68560993-68584936 (-)
CAST/EiJ MGP_CASTEiJ_G0020017
 protein coding gene Chr13:72741996-72770879 (-)
CBA/J MGP_CBAJ_G0020459
 protein coding gene Chr13:79715968-79751590 (-)
DBA/2J MGP_DBA2J_G0020584
 protein coding gene Chr13:71556313-71582511 (-)
FVB/NJ MGP_FVBNJ_G0020564
 protein coding gene Chr13:70578270-70608024 (-)
LP/J MGP_LPJ_G0020657
 protein coding gene Chr13:74630295-74666599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020592
 protein coding gene Chr13:78139313-78166949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021182
 protein coding gene Chr13:73297568-73327746 (-)
PWK/PhJ MGP_PWKPhJ_G0019771
 protein coding gene Chr13:70294335-70320716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019594
 protein coding gene Chr13:69770709-69801535 (-)
WSB/EiJ MGP_WSBEiJ_G0020075
 protein coding gene Chr13:73855483-73886037 (-)



Homology
more
  • Human Ortholog
    TRIP13, thyroid hormone receptor interactor 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIP13, thyroid hormone receptor interactor 13
  • Synonyms
    16E1BP, MVA3, OOMD9, OZEMA9
  • Links
    NCBI Gene ID: 9319
    neXtProt AC: NX_Q15645
    UniProt: Q15645

  • Chr Location
    5p15.33; chr5:892884-919357 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRIP13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 3 genetic backgrounds
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit postnatal lethality, infertility, reduced gonad size, tail defects and meiotic arrest of sperm and oocytes associated with unrepaired double strand breaks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    172
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69716 NCBI Gene Model | MGI Sequence Detail 25279 C57BL/6J ±  kb
    transcript NR_184787 RefSeq | MGI Sequence Detail 2254 ZRU/MplStud  
    polypeptide Q3UA06 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 11
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196282
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:357739 Chotiner JY, et al., TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis. Elife. 2024 Aug 29;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory