Nkiras1 MGI Mouse Gene Detail - MGI:1916971 - NFKB inhibitor interacting Ras-like protein 1

Symbol

Nkiras1
Name

NFKB inhibitor interacting Ras-like protein 1
Synonyms

2400004O09Rik, KBRAS1

Feature Type

protein coding gene
IDs

MGI:1916971
NCBI Gene: 69721
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:4185693-4198560 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 7.08 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

322 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916971	protein coding gene	Chr14:4185693-4198560 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021020	protein coding gene	Chr14:10881412-10895322 (+)
A/J	MGP_AJ_G0020969	protein coding gene	Chr14:10566671-10579617 (+)
AKR/J	MGP_AKRJ_G0020946	protein coding gene	Chr14:10882794-10896820 (+)
BALB/cJ	MGP_BALBcJ_G0020972	protein coding gene	Chr14:10629537-10641457 (+)
C3H/HeJ	MGP_C3HHeJ_G0020756	protein coding gene	Chr14:10964324-10976423 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021405	protein coding gene	Chr14:11274269-11290687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018974	protein coding gene	Chr14:11071308-11088216 (+)
CAST/EiJ	MGP_CASTEiJ_G0020279	protein coding gene	Chr14:10828444-10840864 (+)
CBA/J	MGP_CBAJ_G0020722	protein coding gene	Chr14:11749833-11766221 (+)
DBA/2J	MGP_DBA2J_G0020845	protein coding gene	Chr14:10466874-10479570 (+)
FVB/NJ	MGP_FVBNJ_G0020828	protein coding gene	Chr14:10337103-10349991 (+)
LP/J	MGP_LPJ_G0020921	protein coding gene	Chr14:10948842-10959427 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020854	protein coding gene	Chr14:11630440-11649757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021437	protein coding gene	Chr14:10765575-10780121 (+)
PWK/PhJ	MGP_PWKPhJ_G0020030	protein coding gene	Chr14:10527304-10539699 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019850	protein coding gene	Chr14:10897236-10909297 (+)
WSB/EiJ	MGP_WSBEiJ_G0020335	protein coding gene	Chr14:10813389-10831668 (+)

Human Ortholog

NKIRAS1, NFKB inhibitor interacting Ras like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKIRAS1, NFKB inhibitor interacting Ras like 1
Synonyms

kappaB-Ras1, KBRAS1
Links

HGNC:17899

NCBI Gene ID: 28512

neXtProt AC: NX_Q9NYS0

UniProt: Q9NYS0
Chr Location

3p24.2; chr3:23889951-23946591 (-) GRCh38

MGI Vertebrate Homology

Nkiras1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKIRAS1
Gene Tree

Nkiras1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

10
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

9
cDNA Data

41
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nkiras1

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All Sequences

60
RefSeq

12
UniProt

3
CCDS

CCDS26836.1

Ensembl

ENSMUSG00000021772 (Evidence)
NCBI Gene

69721

			Length	Strain/Species	Flank
genomic	69721	NCBI Gene Model \| MGI Sequence Detail	12868	C57BL/6J	± kb
transcript	NM_001316711	RefSeq \| MGI Sequence Detail	4868	Not Specified
polypeptide	Q8CEC5	UniProt \| EBI \| MGI Sequence Detail	192	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011235 NF-kappa-B inhibitor-interacting Ras-like protein 1

(term hierarchy)
InterPro Domains

IPR042227 NF-kappa-B inhibitor-interacting Ras-like protein

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 41

cDNA 41

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347981 Postler TS, et al., A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2312595120

TSS for Nkiras1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124359	Chr14:4198518-4198574 (-)	14 bp
Tssr124360	Chr14:4198406-4198495 (-)	109 bp
Tssr124361	Chr14:4198375-4198388 (-)	178 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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