Fbxo7 MGI Mouse Gene Detail - MGI:1917004

Symbol

Fbxo7
Name

F-box protein 7
Synonyms

2410015K21Rik, A230052G17Rik

Feature Type

protein coding gene
IDs

MGI:1917004
NCBI Gene: 69754
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:85857836-85887737 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.91 cM
Mapping Data

3 experiments

SNPs within 2kb

660 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917004	protein coding gene	Chr10:85856313-85887737 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017607	protein coding gene	Chr10:86968334-87001077 (+)
A/J	MGP_AJ_G0017587	protein coding gene	Chr10:84072085-84103668 (+)
AKR/J	MGP_AKRJ_G0017547	protein coding gene	Chr10:86425977-86457559 (+)
BALB/cJ	MGP_BALBcJ_G0017550	protein coding gene	Chr10:84300873-84333690 (+)
C3H/HeJ	MGP_C3HHeJ_G0017373	protein coding gene	Chr10:86451268-86482852 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018007	protein coding gene	Chr10:89924301-89957297 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015691	protein coding gene	Chr10:79903032-79934843 (+)
CAST/EiJ	MGP_CASTEiJ_G0016939	protein coding gene	Chr10:86321063-86352999 (+)
CBA/J	MGP_CBAJ_G0017342	protein coding gene	Chr10:93638966-93673134 (+)
DBA/2J	MGP_DBA2J_G0017449	protein coding gene	Chr10:83184622-83216283 (+)
FVB/NJ	MGP_FVBNJ_G0017442	protein coding gene	Chr10:82451671-82485150 (+)
LP/J	MGP_LPJ_G0017521	protein coding gene	Chr10:87644131-87678435 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017470	protein coding gene	Chr10:95272066-95303844 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018044	protein coding gene	Chr10:86295636-86328945 (+)
PWK/PhJ	MGP_PWKPhJ_G0016720	protein coding gene	Chr10:83193215-83223786 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016509	protein coding gene	Chr10:84946935-84976895 (+)
WSB/EiJ	MGP_WSBEiJ_G0016997	protein coding gene	Chr10:86261737-86294131 (+)

Human Ortholog

FBXO7, F-box protein 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO7, F-box protein 7
Synonyms

FBX, FBX07, FBX7, PARK15, PKPS
Links

HGNC:13586

NCBI Gene ID: 25793

neXtProt AC: NX_Q9Y3I1

UniProt: Q9Y3I1
Chr Location

22q12.3; chr22:32474676-32498829 (+) GRCh38

MGI Vertebrate Homology

Fbxo7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO7
Gene Tree

Fbxo7

Diseases

2 with human FBXO7 associations

				Human Disease	Mouse Models
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				Parkinson's disease 15 IDs Parkinson's disease 15 DOID:0060372 OMIM:260300

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

53 phenotypes from 4 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Gene trapped

3
Targeted

7
Genomic Mutations

1 involving Fbxo7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show increased pro-B cell and pro-erythroblast numbers. Homozygotes for a hypomorphic allele show anemia due to a shortened erythrocyte half-life, impaired spermatogenesis, male infertility, altered T cell phenotypes, and increased susceptibility to bacterial infection.

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All GO Annotations

67
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

5
cDNA Data

19
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FBXO7

Xenbase fbxo7

ZFIN fbxo7

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All Sequences

72
RefSeq

10
UniProt

5
CCDS

CCDS24095.1, CCDS78875.1, CCDS83740.1

Ensembl

ENSMUSG00000001786 (Evidence)
NCBI Gene

69754

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001786	Ensembl Gene Model \| MGI Sequence Detail	29902	C57BL/6J	± kb
transcript	ENSMUST00000130320	Ensembl \| MGI Sequence Detail	5388	Not Applicable
polypeptide	ENSMUSP00000120840	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007419 F-box only protein 7

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR047118 F-box only protein 7

IPR021625 PI31 proteasome regulator, N-terminal

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 19

cDNA 19

Microarray probesets 4

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MGI:2143525, MGI:2143831, MGI:2143938, MGI:2444955

Summaries

All 57

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 26
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxo7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94940	Chr10:85857745-85857818 (+)	-54 bp
Tssr94941	Chr10:85857825-85857855 (+)	4 bp
Tssr94942	Chr10:85857857-85857879 (+)	32 bp
Tssr94943	Chr10:85857882-85857891 (+)	51 bp
Tssr94944	Chr10:85857967-85857992 (+)	144 bp
Tssr94945	Chr10:85858072-85858117 (+)	259 bp
Tssr94946	Chr10:85868683-85868693 (+)	10,852 bp
Tssr94947	Chr10:85868826-85868840 (+)	10,997 bp
Tssr94948	Chr10:85868858-85868870 (+)	11,028 bp
Tssr94949	Chr10:85868886-85868894 (+)	11,054 bp
Tssr94950	Chr10:85868902-85868907 (+)	11,069 bp
Tssr94951	Chr10:85868921-85868932 (+)	11,091 bp
Tssr94952	Chr10:85875822-85875869 (+)	18,010 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24