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Tnfaip8l2 Gene Detail
Summary
  • Symbol
    Tnfaip8l2
  • Name
    tumor necrosis factor, alpha-induced protein 8-like 2
  • Synonyms
    1810019A08Rik, Tipe2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917019
    NCBI Gene: 69769
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95046832-95049671 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917019
 protein coding gene Chr3:95046832-95051581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027572
 protein coding gene Chr3:95834270-95837109 (-)
A/J MGP_AJ_G0027531
 protein coding gene Chr3:92880617-92883459 (-)
AKR/J MGP_AKRJ_G0027498
 protein coding gene Chr3:95023494-95026336 (-)
BALB/cJ MGP_BALBcJ_G0027543
 protein coding gene Chr3:92649997-92652839 (-)
C3H/HeJ MGP_C3HHeJ_G0027276
 protein coding gene Chr3:95302965-95305807 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027991
 protein coding gene Chr3:99401719-99404558 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025331
 protein coding gene Chr3:89239925-89242766 (-)
CAST/EiJ MGP_CASTEiJ_G0026726
 protein coding gene Chr3:94587422-94590252 (-)
CBA/J MGP_CBAJ_G0027253
 protein coding gene Chr3:103006852-103009694 (-)
DBA/2J MGP_DBA2J_G0027392
 protein coding gene Chr3:92173024-92175866 (-)
FVB/NJ MGP_FVBNJ_G0027363
 protein coding gene Chr3:90241121-90243963 (-)
LP/J MGP_LPJ_G0027501
 protein coding gene Chr3:97130415-97133254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027390
 protein coding gene Chr3:109132735-109135574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028045
 protein coding gene Chr3:94678108-94680950 (-)
PWK/PhJ MGP_PWKPhJ_G0026454
 protein coding gene Chr3:92047676-92050521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026275
 protein coding gene Chr3:92971793-92974631 (-)
WSB/EiJ MGP_WSBEiJ_G0026808
 protein coding gene Chr3:95060972-95063813 (-)



Homology
more
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
  • Synonyms
    TIPE2
  • Links
    NCBI Gene ID: 79626
    neXtProt AC: NX_Q6P589
    UniProt: Q6P589

  • Chr Location
    1q21.3; chr1:151156649-151159749 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 50% of mice homozygous for a null allele die prematurely of a chronic disease characterized by weight loss, splenomegaly, leukocytosis, and multiorgan inflammation; mutants are hypersensitive to septic shock while cells are hyperresponsive to Toll-like receptor and T cell receptor activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013707 Ensembl Gene Model | MGI Sequence Detail 2840 C57BL/6J ±  kb
    transcript ENSMUST00000013851 Ensembl | MGI Sequence Detail 1122 Not Applicable  
    polypeptide ENSMUSP00000013851 Ensembl | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016478 tumor necrosis factor alpha-induced protein 8-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008477 Tumor necrosis factor alpha-induced protein 8-like
      IPR038355 Tumor necrosis factor alpha-induced protein 8-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140012
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory