Bdh2 MGI Mouse Gene Detail - MGI:1917022 - 3-hydroxybutyrate dehydrogenase, type 2

Symbol

Bdh2
Name

3-hydroxybutyrate dehydrogenase, type 2
Synonyms

1810026B04Rik, Dhrs6

Feature Type

protein coding gene
IDs

MGI:1917022
NCBI Gene: 69772
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:134986982-135010187 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 62.55 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1056 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917022	protein coding gene	Chr3:134986982-135010187 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027903	protein coding gene	Chr3:138149170-138176460 (+)
A/J	MGP_AJ_G0027861	protein coding gene	Chr3:133302477-133326731 (+)
AKR/J	MGP_AKRJ_G0027826	protein coding gene	Chr3:136831071-136859028 (+)
BALB/cJ	MGP_BALBcJ_G0027874	protein coding gene	Chr3:133160173-133183320 (+)
C3H/HeJ	MGP_C3HHeJ_G0027603	protein coding gene	Chr3:137172596-137196878 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028317	protein coding gene	Chr3:142991100-143015613 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025655	protein coding gene	Chr3:128546604-128570081 (+)
CAST/EiJ	MGP_CASTEiJ_G0027059	protein coding gene	Chr3:136903310-136928097 (+)
CBA/J	MGP_CBAJ_G0027579	protein coding gene	Chr3:147831255-147855856 (+)
DBA/2J	MGP_DBA2J_G0027719	protein coding gene	Chr3:132469095-132492319 (+)
FVB/NJ	MGP_FVBNJ_G0027686	protein coding gene	Chr3:129959478-129982996 (+)
LP/J	MGP_LPJ_G0027829	protein coding gene	Chr3:139592021-139616671 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027717	protein coding gene	Chr3:155952105-155976130 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028375	protein coding gene	Chr3:136371793-136397133 (+)
PWK/PhJ	MGP_PWKPhJ_G0026783	protein coding gene	Chr3:132181095-132205015 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026609	protein coding gene	Chr3:134450262-134473560 (+)
WSB/EiJ	MGP_WSBEiJ_G0027138	protein coding gene	Chr3:137159286-137184671 (+)

Human Ortholog

BDH2, 3-hydroxybutyrate dehydrogenase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BDH2, 3-hydroxybutyrate dehydrogenase 2
Synonyms

DHRS6, EFA6R, PRO20933, SDR15C1, UCPA-OR, UNQ6308
Links

HGNC:32389

NCBI Gene ID: 56898

neXtProt AC: NX_Q9BUT1

UniProt: Q9BUT1
Chr Location

4q24

MGI Vertebrate Homology

Bdh2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BDH2
Gene Tree

Bdh2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Bdh2
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

955
Tissues

249
cDNA Data

35
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bdh2

ZFIN bdh2

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS17853.1, CCDS51073.1

Ensembl

ENSMUSG00000028167 (Evidence)
NCBI Gene

69772

			Length	Strain/Species	Flank
genomic	69772	NCBI Gene Model \| MGI Sequence Detail	23206	C57BL/6J	± kb
transcript	NM_001172055	RefSeq \| MGI Sequence Detail	1172	C57BL/6
polypeptide	Q8JZV9	UniProt \| EBI \| MGI Sequence Detail	245	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004715 dehydrogenase/reductase SDR family member 6

(term hierarchy)
EC

1.1.1.-, 1.1.1.104, 1.1.1.30
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

IPR051122 Short-chain dehydrogenase/reductase superfamily enzyme

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All nucleic 35

cDNA 35

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bdh2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31798	Chr3:134987035-134987060 (+)	66 bp
Tssr31799	Chr3:134987061-134987093 (+)	95 bp
Tssr31800	Chr3:135004542-135004595 (+)	17,587 bp
Tssr31801	Chr3:135004608-135004622 (+)	17,633 bp
Tssr31802	Chr3:135004633-135004678 (+)	17,674 bp
Tssr31803	Chr3:135004694-135004701 (+)	17,716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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