Tprkb MGI Mouse Gene Detail - MGI:1917036

Symbol

Tprkb
Name

Tp53rk binding protein
Synonyms

0610033G21Rik, 1810034M08Rik, DRWMS1

Feature Type

protein coding gene
IDs

MGI:1917036
NCBI Gene: 69786
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:85888847-85907266 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.53 cM
Mapping Data

1 experiment

SNPs within 2kb

412 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917036	protein coding gene	Chr6:85888842-85907266 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030967	protein coding gene	Chr6:87154821-87174557 (+)
A/J	MGP_AJ_G0030933	protein coding gene	Chr6:83801752-83819880 (+)
AKR/J	MGP_AKRJ_G0030864	protein coding gene	Chr6:86233480-86252617 (+)
BALB/cJ	MGP_BALBcJ_G0030946	protein coding gene	Chr6:83788172-83806295 (+)
C3H/HeJ	MGP_C3HHeJ_G0030764	protein coding gene	Chr6:98217632-98235718 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031403	protein coding gene	Chr6:89525289-89543549 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028587	protein coding gene	Chr6:81925399-81978421 (+)
CAST/EiJ	MGP_CASTEiJ_G0030055	protein coding gene	Chr6:86271147-86293090 (+)
CBA/J	MGP_CBAJ_G0030630	protein coding gene	Chr6:93042863-93065691 (+)
DBA/2J	MGP_DBA2J_G0030786	protein coding gene	Chr6:83122910-83140346 (+)
FVB/NJ	MGP_FVBNJ_G0030739	protein coding gene	Chr6:82297363-82314757 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0030772	protein coding gene	Chr6:97201387-97221493 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031430	protein coding gene	Chr6:86064538-86083202 (+)
PWK/PhJ	MGP_PWKPhJ_G0029770	protein coding gene	Chr6:82052644-82070896 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029598	protein coding gene	Chr6:84909341-84931059 (+)
WSB/EiJ	MGP_WSBEiJ_G0030136	protein coding gene	Chr6:86512287-86531277 (+)

Human Ortholog

TPRKB, TP53RK binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPRKB, TP53RK binding protein
Synonyms

CGI-121, CGI121, GAMOS5
Links

HGNC:24259

NCBI Gene ID: 51002

neXtProt AC: NX_Q9Y3C4

UniProt: Q9Y3C4
Chr Location

2p13.1; chr2:73729104-73737400 (-) GRCh38

MGI Vertebrate Homology

Tprkb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPRKB
Gene Tree

Tprkb

Diseases

1 with human TPRKB associations

				Human Disease	Mouse Models
				Galloway-Mowat syndrome 5 IDs Galloway-Mowat syndrome 5 DOID:0080247 OMIM:617731

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

4
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Tprkb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

Mice homozygous for a null allele die prior to E7.5.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

61
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tprkb

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All Sequences

84
RefSeq

20
UniProt

7
CCDS

CCDS20305.1, CCDS90081.1

Ensembl

ENSMUSG00000054226 (Evidence)
NCBI Gene

69786

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054226	Ensembl Gene Model \| MGI Sequence Detail	18420	C57BL/6J	± kb
transcript	ENSMUST00000200680	Ensembl \| MGI Sequence Detail	814	Not Applicable
polypeptide	ENSMUSP00000144160	Ensembl \| MGI Sequence Detail	175	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016591 EKC/KEOPS complex subunit TPRKB

(term hierarchy)
InterPro Domains

IPR013926 CGI121/TPRKB

IPR036504 CGI121/TPRKB superfamily

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All nucleic 61

cDNA 61

Microarray probesets 6

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MGI:1922059

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tprkb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57429	Chr6:85888836-85888847 (+)	-5 bp
Tssr57430	Chr6:85888849-85888867 (+)	11 bp
Tssr57431	Chr6:85892691-85892752 (+)	3,875 bp
Tssr57432	Chr6:85892769-85892780 (+)	3,928 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24