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Med6 Gene Detail
Summary
  • Symbol
    Med6
  • Name
    mediator complex subunit 6
  • Synonyms
    1500012F11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917042
    NCBI Gene: 69792
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81620331-81641782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.80 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917042
 protein coding gene Chr12:81620331-81641782 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019905
 protein coding gene Chr12:82046645-82072421 (-)
A/J MGP_AJ_G0019862
 protein coding gene Chr12:79048215-79067916 (-)
AKR/J MGP_AKRJ_G0019838
 protein coding gene Chr12:81194772-81214694 (-)
BALB/cJ MGP_BALBcJ_G0019842
 protein coding gene Chr12:79272799-79290871 (-)
C3H/HeJ MGP_C3HHeJ_G0019648
 protein coding gene Chr12:81657232-81677771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020294
 protein coding gene Chr12:84433765-84455194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017911
 protein coding gene Chr12:76018145-76036166 (-)
CAST/EiJ MGP_CASTEiJ_G0019197
 protein coding gene Chr12:76545103-76564890 (-)
CBA/J MGP_CBAJ_G0019619
 protein coding gene Chr12:87701702-87728077 (-)
DBA/2J MGP_DBA2J_G0019734
 protein coding gene Chr12:78626289-78646091 (-)
FVB/NJ MGP_FVBNJ_G0019720
 protein coding gene Chr12:77475014-77496488 (-)
LP/J MGP_LPJ_G0019806
 protein coding gene Chr12:81954596-81986998 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019759
 protein coding gene Chr12:90712214-90730182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020328
 protein coding gene Chr12:80724583-80743364 (-)
PWK/PhJ MGP_PWKPhJ_G0018962
 protein coding gene Chr12:73035167-73052161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018756
 protein coding gene Chr12:75244628-75260894 (-)
WSB/EiJ MGP_WSBEiJ_G0019249
 protein coding gene Chr12:81372458-81394825 (-)



Homology
more
  • Human Ortholog
    MED6, mediator complex subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED6, mediator complex subunit 6
  • Synonyms
    ARC33, NY-REN-28
  • Links
    NCBI Gene ID: 10001
    neXtProt AC: NX_O75586
    UniProt: O75586

  • Chr Location
    14q24.2; chr14:70581257-70600690 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    39
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69792 NCBI Gene Model | MGI Sequence Detail 21452 C57BL/6J ±  kb
transcript NM_001347386 RefSeq | MGI Sequence Detail 1128 C57BL/6  
polypeptide Q921D4 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 11
Other
Accession IDs
less
MGI:2144950, MGI:2144985
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 13
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory